TY - JOUR
T1 - Documentation of decline in morbidity in women undergoing coronary angioplasty (A report from the 1993-94 NHLBI percutaneous transluminal coronary angioplasty registry)
AU - Jacobs, Alice K.
AU - Kelsey, Sheryl F.
AU - Yeh, Wanlin
AU - Holmes, David R.
AU - Block, Peter C.
AU - Cowley, Michael J.
AU - Bourassa, Martial G.
AU - Williams, David O.
AU - King, Spencer B.
AU - Faxon, David P.
AU - Myler, Richard
AU - Detre, Katherine M.
N1 - Funding Information:
From the Evans Memorral Department of Climcal Research and the Section of Cardiology, Department of Medicine, Boston Medical Center, Boston, Massachusetts; the Department of Epidemiology, Graduate School of Public He&h, University of Prttsburgh, Pittsburgh, Pennsylvania; the Division of Cardiovascular Diseases and Internal Medicrne, Mayo Clinrc, Rochester, Minnesota; Sarnt Vrncent Heart Institute, Portland, Oregon; the Division of Cardrology, Department of Medrcrne, The Medical College of Virgrnra, Rrchmond, Virginia, the lnstitut de Cardiologie de Montreal, Montreal, Quebec, Canada, Rhode Island Hospital, Brown Universrty Hospital, Providence, Rhode Island; Andreas Gruentzig Cardrovascular Center, Emory University Hospital, Atlanta, Georgia; Drvisron of Cardiology, University of Southern California, Los Angeles, Californra, and San Francisco Heart lnstrtute at Seton Medical Center, Daly City, Calrfornra This study was supported by the Office of Research on Women’s Health as a supplement to Natronal Institutes of Health Grant 5UOl Hl3392-09, Bethesda, Maryland. Manuscrrpt received February 25, 1997; revised manuscript received and accepted June 13, 1997.
PY - 1997/10/15
Y1 - 1997/10/15
N2 - To determine whether there has been an improvement in the relatively unfavorable outcome of percutaneous transluminal coronary angioplasty (PTCA) in women, the 1993 to 1994 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry collected date from 12 clinical centers that participated in the earlier registries. We compared 274 consecutive women in 1993 to 1994 with 545 consecutive women in 1985 to 1986 undergoing PTCA. Women in the 1993 to 1994 registry were older (64.3 vs 61.0 years, p <0.001) with more diabetes mellitus (34.3% vs 19.9%, p <0.001), congestive heart failure (13.7% vs 8.6%, p <0.05), and comorbid disease (19.5% vs 9.3%, p <0.001). Left ventricular function and multivessel coronary artery disease were similar between groups. Angiographic success (90.9% vs 85.1%, p <0.05) and clinical/success (89.4% vs 79.4%, p <0.001) were higher in women undergoing PTCA in 1993 to 1994 than in 1985 to 1986. Whereas there was no difference in in-hospital mortality (1.5% vs 2.6%), the incidence of nonfatal myocardial infarction (1.8% vs 4.6%, p <0.05), emergency coronary artery bypass graft surgery (1.8% vs 4.6%, p <0.05), and the combined end points of death, myocardial infarction, and emergency coronary artery bypass grafting (4.4% vs 9.7%, p <0.01) were lower in women in 1993 to 1994 than in women in 1985 to 1986, respectively. Multivariate analysis revealed an odds ratio of 0.36 (95% confidence interval 0.18 to 0.72) for major complications and of 2.34 (95% confidence interval, 1.49 to 3.69) for clinical success in the 1993 to 1994 versus 1985 to 1986 registry. Therefore, despite a higher risk profile, women undergoing PTCA in 1993 to 1994 have a higher clinical success and lower major complication rate than women treated with PTCA in 1985 to 1986.
AB - To determine whether there has been an improvement in the relatively unfavorable outcome of percutaneous transluminal coronary angioplasty (PTCA) in women, the 1993 to 1994 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry collected date from 12 clinical centers that participated in the earlier registries. We compared 274 consecutive women in 1993 to 1994 with 545 consecutive women in 1985 to 1986 undergoing PTCA. Women in the 1993 to 1994 registry were older (64.3 vs 61.0 years, p <0.001) with more diabetes mellitus (34.3% vs 19.9%, p <0.001), congestive heart failure (13.7% vs 8.6%, p <0.05), and comorbid disease (19.5% vs 9.3%, p <0.001). Left ventricular function and multivessel coronary artery disease were similar between groups. Angiographic success (90.9% vs 85.1%, p <0.05) and clinical/success (89.4% vs 79.4%, p <0.001) were higher in women undergoing PTCA in 1993 to 1994 than in 1985 to 1986. Whereas there was no difference in in-hospital mortality (1.5% vs 2.6%), the incidence of nonfatal myocardial infarction (1.8% vs 4.6%, p <0.05), emergency coronary artery bypass graft surgery (1.8% vs 4.6%, p <0.05), and the combined end points of death, myocardial infarction, and emergency coronary artery bypass grafting (4.4% vs 9.7%, p <0.01) were lower in women in 1993 to 1994 than in women in 1985 to 1986, respectively. Multivariate analysis revealed an odds ratio of 0.36 (95% confidence interval 0.18 to 0.72) for major complications and of 2.34 (95% confidence interval, 1.49 to 3.69) for clinical success in the 1993 to 1994 versus 1985 to 1986 registry. Therefore, despite a higher risk profile, women undergoing PTCA in 1993 to 1994 have a higher clinical success and lower major complication rate than women treated with PTCA in 1985 to 1986.
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U2 - 10.1016/S0002-9149(97)00588-2
DO - 10.1016/S0002-9149(97)00588-2
M3 - Article
C2 - 9352963
AN - SCOPUS:0030685826
SN - 0002-9149
VL - 80
SP - 979
EP - 984
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 8
ER -