Documentation of decline in morbidity in women undergoing coronary angioplasty (A report from the 1993-94 NHLBI percutaneous transluminal coronary angioplasty registry)

Alice K. Jacobs, Sheryl F. Kelsey, Wanlin Yeh, David R. Holmes, Peter C. Block, Michael J. Cowley, Martial G. Bourassa, David O. Williams, Spencer B. King, David P. Faxon, Richard Myler, Katherine M. Detre

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45 Scopus citations

Abstract

To determine whether there has been an improvement in the relatively unfavorable outcome of percutaneous transluminal coronary angioplasty (PTCA) in women, the 1993 to 1994 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry collected date from 12 clinical centers that participated in the earlier registries. We compared 274 consecutive women in 1993 to 1994 with 545 consecutive women in 1985 to 1986 undergoing PTCA. Women in the 1993 to 1994 registry were older (64.3 vs 61.0 years, p <0.001) with more diabetes mellitus (34.3% vs 19.9%, p <0.001), congestive heart failure (13.7% vs 8.6%, p <0.05), and comorbid disease (19.5% vs 9.3%, p <0.001). Left ventricular function and multivessel coronary artery disease were similar between groups. Angiographic success (90.9% vs 85.1%, p <0.05) and clinical/success (89.4% vs 79.4%, p <0.001) were higher in women undergoing PTCA in 1993 to 1994 than in 1985 to 1986. Whereas there was no difference in in-hospital mortality (1.5% vs 2.6%), the incidence of nonfatal myocardial infarction (1.8% vs 4.6%, p <0.05), emergency coronary artery bypass graft surgery (1.8% vs 4.6%, p <0.05), and the combined end points of death, myocardial infarction, and emergency coronary artery bypass grafting (4.4% vs 9.7%, p <0.01) were lower in women in 1993 to 1994 than in women in 1985 to 1986, respectively. Multivariate analysis revealed an odds ratio of 0.36 (95% confidence interval 0.18 to 0.72) for major complications and of 2.34 (95% confidence interval, 1.49 to 3.69) for clinical success in the 1993 to 1994 versus 1985 to 1986 registry. Therefore, despite a higher risk profile, women undergoing PTCA in 1993 to 1994 have a higher clinical success and lower major complication rate than women treated with PTCA in 1985 to 1986.

Original languageEnglish (US)
Pages (from-to)979-984
Number of pages6
JournalAmerican Journal of Cardiology
Volume80
Issue number8
DOIs
StatePublished - Oct 15 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Jacobs, A. K., Kelsey, S. F., Yeh, W., Holmes, D. R., Block, P. C., Cowley, M. J., Bourassa, M. G., Williams, D. O., King, S. B., Faxon, D. P., Myler, R., & Detre, K. M. (1997). Documentation of decline in morbidity in women undergoing coronary angioplasty (A report from the 1993-94 NHLBI percutaneous transluminal coronary angioplasty registry). American Journal of Cardiology, 80(8), 979-984. https://doi.org/10.1016/S0002-9149(97)00588-2