Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis

Mohamed Salah Annabi, Eden Touboul, Abdellaziz Dahou, Ian G. Burwash, Jutta Bergler-Klein, Maurice E Sarano, Stefan Orwat, Helmut Baumgartner, Julia Mascherbauer, Gerald Mundigler, João L. Cavalcante, Éric Larose, Philippe Pibarot, Marie Annick Clavel

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: In the American College of Cardiology/American Heart Association guidelines, patients are considered to have true-severe stenosis when the mean gradient (MG) is ≥40 mm Hg with an aortic valve area (AVA) ≤1 cm2 during dobutamine stress echocardiography (DSE). However, these criteria have not been previously validated. Objectives: The aim of this study was to assess the value of these criteria to predict the presence of true-severe AS and the occurrence of death in patients with low-flow, low-gradient aortic stenosis (LF-LG AS). Methods: One hundred eighty-six patients with low left ventricular ejection fraction (LVEF) LF-LG AS were prospectively recruited and underwent DSE, with measurement of the MG, AVA, and the projected AVA (AVAProj), which is an estimate of the AVA at a standardized normal flow rate. Severity of AS was independently corroborated by macroscopic evaluation of the valve at the time of valve replacement in 54 patients, by measurement of the aortic valve calcium by computed tomography in 25 patients, and by both methods in 8 patients. According to these assessments, 50 of 87 (57%) patients in the study cohort had true-severe stenosis. Results: Peak stress MG ≥40 mm Hg, peak stress AVA ≤1 cm2, and the combination of peak stress MG ≥40 mm Hg and peak stress AVA ≤1 cm2 correctly classified AS severity in 48%, 60%, and 47% of patients, respectively, whereas AVAProj ≤1 cm2 was better than all the previous markers (p < 0.007), with 70% correct classification. Among the subset of 88 patients managed conservatively (47% of the cohort), 52 died during a follow-up of 2.8 ± 2.5 years. After adjustment for age, sex, functional capacity, chronic kidney failure, and peak stress LVEF, peak stress MG and AVA were not predictors of mortality in this subset. In contrast, AVAProj ≤1 cm2 was a strong predictor of mortality under medical management (hazard ratio: 3.65; p = 0.0003). Conclusions: In patients with low LVEF LF-LG AS, the DSE criteria of a peak stress MG ≥40 mm Hg, or the composite of a peak stress MG ≥40 mm Hg and a peak stress AVA ≤1 cm2 proposed in the guidelines to identify true-severe AS and recommend valve replacement, have limited value to predict actual stenosis severity and outcomes. In contrast, AVAProj better distinguishes true-severe AS from pseudo-severe AS and is strongly associated with mortality in patients under conservative management. (Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis [TOPAS]; NCT01835028)

Original languageEnglish (US)
Pages (from-to)475-485
Number of pages11
JournalJournal of the American College of Cardiology
Volume71
Issue number5
DOIs
StatePublished - Feb 6 2018

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Stress Echocardiography
Aortic Valve Stenosis
Aortic Valve
Stroke Volume
Pathologic Constriction
Mortality
Guidelines
Safety Management
Multicenter Studies
Chronic Kidney Failure
Cohort Studies
Tomography
Prospective Studies

Keywords

  • aortic stenosis
  • LV dysfunction
  • stress echocardiography
  • survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis. / Annabi, Mohamed Salah; Touboul, Eden; Dahou, Abdellaziz; Burwash, Ian G.; Bergler-Klein, Jutta; Sarano, Maurice E; Orwat, Stefan; Baumgartner, Helmut; Mascherbauer, Julia; Mundigler, Gerald; Cavalcante, João L.; Larose, Éric; Pibarot, Philippe; Clavel, Marie Annick.

In: Journal of the American College of Cardiology, Vol. 71, No. 5, 06.02.2018, p. 475-485.

Research output: Contribution to journalArticle

Annabi, MS, Touboul, E, Dahou, A, Burwash, IG, Bergler-Klein, J, Sarano, ME, Orwat, S, Baumgartner, H, Mascherbauer, J, Mundigler, G, Cavalcante, JL, Larose, É, Pibarot, P & Clavel, MA 2018, 'Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis', Journal of the American College of Cardiology, vol. 71, no. 5, pp. 475-485. https://doi.org/10.1016/j.jacc.2017.11.052
Annabi, Mohamed Salah ; Touboul, Eden ; Dahou, Abdellaziz ; Burwash, Ian G. ; Bergler-Klein, Jutta ; Sarano, Maurice E ; Orwat, Stefan ; Baumgartner, Helmut ; Mascherbauer, Julia ; Mundigler, Gerald ; Cavalcante, João L. ; Larose, Éric ; Pibarot, Philippe ; Clavel, Marie Annick. / Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis. In: Journal of the American College of Cardiology. 2018 ; Vol. 71, No. 5. pp. 475-485.
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TY - JOUR

T1 - Dobutamine Stress Echocardiography for Management of Low-Flow, Low-Gradient Aortic Stenosis

AU - Annabi, Mohamed Salah

AU - Touboul, Eden

AU - Dahou, Abdellaziz

AU - Burwash, Ian G.

AU - Bergler-Klein, Jutta

AU - Sarano, Maurice E

AU - Orwat, Stefan

AU - Baumgartner, Helmut

AU - Mascherbauer, Julia

AU - Mundigler, Gerald

AU - Cavalcante, João L.

AU - Larose, Éric

AU - Pibarot, Philippe

AU - Clavel, Marie Annick

PY - 2018/2/6

Y1 - 2018/2/6

N2 - Background: In the American College of Cardiology/American Heart Association guidelines, patients are considered to have true-severe stenosis when the mean gradient (MG) is ≥40 mm Hg with an aortic valve area (AVA) ≤1 cm2 during dobutamine stress echocardiography (DSE). However, these criteria have not been previously validated. Objectives: The aim of this study was to assess the value of these criteria to predict the presence of true-severe AS and the occurrence of death in patients with low-flow, low-gradient aortic stenosis (LF-LG AS). Methods: One hundred eighty-six patients with low left ventricular ejection fraction (LVEF) LF-LG AS were prospectively recruited and underwent DSE, with measurement of the MG, AVA, and the projected AVA (AVAProj), which is an estimate of the AVA at a standardized normal flow rate. Severity of AS was independently corroborated by macroscopic evaluation of the valve at the time of valve replacement in 54 patients, by measurement of the aortic valve calcium by computed tomography in 25 patients, and by both methods in 8 patients. According to these assessments, 50 of 87 (57%) patients in the study cohort had true-severe stenosis. Results: Peak stress MG ≥40 mm Hg, peak stress AVA ≤1 cm2, and the combination of peak stress MG ≥40 mm Hg and peak stress AVA ≤1 cm2 correctly classified AS severity in 48%, 60%, and 47% of patients, respectively, whereas AVAProj ≤1 cm2 was better than all the previous markers (p < 0.007), with 70% correct classification. Among the subset of 88 patients managed conservatively (47% of the cohort), 52 died during a follow-up of 2.8 ± 2.5 years. After adjustment for age, sex, functional capacity, chronic kidney failure, and peak stress LVEF, peak stress MG and AVA were not predictors of mortality in this subset. In contrast, AVAProj ≤1 cm2 was a strong predictor of mortality under medical management (hazard ratio: 3.65; p = 0.0003). Conclusions: In patients with low LVEF LF-LG AS, the DSE criteria of a peak stress MG ≥40 mm Hg, or the composite of a peak stress MG ≥40 mm Hg and a peak stress AVA ≤1 cm2 proposed in the guidelines to identify true-severe AS and recommend valve replacement, have limited value to predict actual stenosis severity and outcomes. In contrast, AVAProj better distinguishes true-severe AS from pseudo-severe AS and is strongly associated with mortality in patients under conservative management. (Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis [TOPAS]; NCT01835028)

AB - Background: In the American College of Cardiology/American Heart Association guidelines, patients are considered to have true-severe stenosis when the mean gradient (MG) is ≥40 mm Hg with an aortic valve area (AVA) ≤1 cm2 during dobutamine stress echocardiography (DSE). However, these criteria have not been previously validated. Objectives: The aim of this study was to assess the value of these criteria to predict the presence of true-severe AS and the occurrence of death in patients with low-flow, low-gradient aortic stenosis (LF-LG AS). Methods: One hundred eighty-six patients with low left ventricular ejection fraction (LVEF) LF-LG AS were prospectively recruited and underwent DSE, with measurement of the MG, AVA, and the projected AVA (AVAProj), which is an estimate of the AVA at a standardized normal flow rate. Severity of AS was independently corroborated by macroscopic evaluation of the valve at the time of valve replacement in 54 patients, by measurement of the aortic valve calcium by computed tomography in 25 patients, and by both methods in 8 patients. According to these assessments, 50 of 87 (57%) patients in the study cohort had true-severe stenosis. Results: Peak stress MG ≥40 mm Hg, peak stress AVA ≤1 cm2, and the combination of peak stress MG ≥40 mm Hg and peak stress AVA ≤1 cm2 correctly classified AS severity in 48%, 60%, and 47% of patients, respectively, whereas AVAProj ≤1 cm2 was better than all the previous markers (p < 0.007), with 70% correct classification. Among the subset of 88 patients managed conservatively (47% of the cohort), 52 died during a follow-up of 2.8 ± 2.5 years. After adjustment for age, sex, functional capacity, chronic kidney failure, and peak stress LVEF, peak stress MG and AVA were not predictors of mortality in this subset. In contrast, AVAProj ≤1 cm2 was a strong predictor of mortality under medical management (hazard ratio: 3.65; p = 0.0003). Conclusions: In patients with low LVEF LF-LG AS, the DSE criteria of a peak stress MG ≥40 mm Hg, or the composite of a peak stress MG ≥40 mm Hg and a peak stress AVA ≤1 cm2 proposed in the guidelines to identify true-severe AS and recommend valve replacement, have limited value to predict actual stenosis severity and outcomes. In contrast, AVAProj better distinguishes true-severe AS from pseudo-severe AS and is strongly associated with mortality in patients under conservative management. (Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis [TOPAS]; NCT01835028)

KW - aortic stenosis

KW - LV dysfunction

KW - stress echocardiography

KW - survival

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