Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans

Sonia Velez-Roa, Baktybek Kojonazarov, Agnieszka Ciarka, Pascal Godart, Robert Naeije, Virend K. Somers, Philippe Van de Borne

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

β-Adrenergic agonists may increase chemosensitivity in humans. We tested the hypothesis that the β1-agonist dobutamine increases peripheral chemosensitivity in a double-blind placebo-controlled randomized and crossover study. In 15 healthy subjects, we examined the effects of dobutamine on breathing, hemodynamics, and sympathetic nerve activity (measured using microneurography) during normoxia, isocapnic hypoxia (10% O2), posthypoxic maximal voluntary end-expiratory apnea, hyperoxic hypercapnia, and cold pressor test (CPT). Dobutamine increased ventilation (7.5 ± 0.3 vs. 6.7 ± 0.2 l/min, P = 0.0004) during normoxia, markedly enhanced the ventilatory (16.1 ± 1.6 vs. 11.4 ± 0.7 l/min, P < 0.0001) and sympathetic (+403 ± 94 vs. +222 ± 5%, P < 0.03) responses at the fifth minute of isocapnic hypoxia, and enhanced the sympathetic response to the apnea performed after hypoxia (+501 ± 107% vs. +291 ± 38%, P < 0.05). No differences were observed between dobutamine and placebo on the responses to hyperoxic hypercapnia and CPT. Dobutamine increases ventilation during normoxia and potentiates the ventilatory and sympathetic responses to hypoxia in healthy subjects. Dobutamine does not affect the responses to hyperoxic hypercapnia and CPT. We conclude that dobutamine enhances peripheral chemosensitivity.

Original languageEnglish (US)
Pages (from-to)H1356-H1361
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume285
Issue number3 54-3
DOIs
StatePublished - Sep 1 2003

Keywords

  • Hypoxia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans'. Together they form a unique fingerprint.

  • Cite this