¿Influyen el número y volumen de las biopsias pulmonares en el rendimiento diagnóstico en la enfermedad pulmonar intersticial? Análisis mediante índice de propensión

Translated title of the contribution: Do the number and volume of surgical lung biopsies influence the diagnostic yield in interstitial lung disease? A propensity score analysis

Juan J. Fibla, Alessandro Brunelli, Mark S. Allen, Dennis A Wigle, Robert Shen, Francis Nichols, Claude Deschamps, Stephen D. Cassivi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Our objective was to evaluate whether the number and volume of surgical lung biopsies (SLB) influence the diagnosis of diffuse interstitial lung disease (ILD). Methods: Retrospective study of SLB for suspected ILD in patients from the Mayo Clinic from January 2002 to January 2010. Data were collected in the institution and analyzed. Results: 311 patients were studied. Mean number of biopsies was 2.05 (SD 0.6); 1 biopsy in 50 (16%), 2 in 198 (63.7%), 3 in 59 (19%) and 4 in 4 (1.3%). Histopathologic diagnosis was: definitive (specific): 232 (74.6%), descriptive (non-specific): 76 (24.4%), no diagnosis: 3 (1%). After excluding patients without diagnosis (n=3), there were 50 patients with only 1 biopsy, 196 with 2 and 62 with 3 or 4; the definitive diagnostic yield was similar in all 3 groups (37/50; 74%, 150/196; 77%, and 45/62; 73%) (Chi-square, p value 0.8). The propensity score analysis between patients with 1 SLB and patients with more than 1 SLB also showed no difference in diagnostic yield. Regarding the volume of biopsies, mean total volume was 34.4cm3 (SD 46): 41.2cm3 (3 cases) in patients with no diagnosis; 33.6cm3 (232 cases, SD 47) in patients with specific diagnosis; and 36.6cm3 (76 cases, SD 44) in patients with descriptive diagnosis. Biopsy volume had no influence on histopathology yield (ANOVA, p value 0.8). Conclusions: The number and volume of the biopsy specimens in SLB did not seem to influence diagnosis. Based on our results, we believe a single sample from a representative area may be sufficient for diagnosis. Randomized prospective trials should be performed to optimize SLB for ILD.

Original languageSpanish
Pages (from-to)76-79
Number of pages4
JournalArchivos de Bronconeumologia
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Propensity Score
Interstitial Lung Diseases
Biopsy
Lung
Analysis of Variance
Retrospective Studies

Keywords

  • Diagnostic yield
  • Interstitial lung disease
  • Surgical lung biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

¿Influyen el número y volumen de las biopsias pulmonares en el rendimiento diagnóstico en la enfermedad pulmonar intersticial? Análisis mediante índice de propensión. / Fibla, Juan J.; Brunelli, Alessandro; Allen, Mark S.; Wigle, Dennis A; Shen, Robert; Nichols, Francis; Deschamps, Claude; Cassivi, Stephen D.

In: Archivos de Bronconeumologia, Vol. 51, No. 2, 01.02.2015, p. 76-79.

Research output: Contribution to journalArticle

Fibla, Juan J. ; Brunelli, Alessandro ; Allen, Mark S. ; Wigle, Dennis A ; Shen, Robert ; Nichols, Francis ; Deschamps, Claude ; Cassivi, Stephen D. / ¿Influyen el número y volumen de las biopsias pulmonares en el rendimiento diagnóstico en la enfermedad pulmonar intersticial? Análisis mediante índice de propensión. In: Archivos de Bronconeumologia. 2015 ; Vol. 51, No. 2. pp. 76-79.
@article{3922771e4cbe4952b431dbcacf9cfa58,
title = "¿Influyen el n{\'u}mero y volumen de las biopsias pulmonares en el rendimiento diagn{\'o}stico en la enfermedad pulmonar intersticial? An{\'a}lisis mediante {\'i}ndice de propensi{\'o}n",
abstract = "Introduction: Our objective was to evaluate whether the number and volume of surgical lung biopsies (SLB) influence the diagnosis of diffuse interstitial lung disease (ILD). Methods: Retrospective study of SLB for suspected ILD in patients from the Mayo Clinic from January 2002 to January 2010. Data were collected in the institution and analyzed. Results: 311 patients were studied. Mean number of biopsies was 2.05 (SD 0.6); 1 biopsy in 50 (16{\%}), 2 in 198 (63.7{\%}), 3 in 59 (19{\%}) and 4 in 4 (1.3{\%}). Histopathologic diagnosis was: definitive (specific): 232 (74.6{\%}), descriptive (non-specific): 76 (24.4{\%}), no diagnosis: 3 (1{\%}). After excluding patients without diagnosis (n=3), there were 50 patients with only 1 biopsy, 196 with 2 and 62 with 3 or 4; the definitive diagnostic yield was similar in all 3 groups (37/50; 74{\%}, 150/196; 77{\%}, and 45/62; 73{\%}) (Chi-square, p value 0.8). The propensity score analysis between patients with 1 SLB and patients with more than 1 SLB also showed no difference in diagnostic yield. Regarding the volume of biopsies, mean total volume was 34.4cm3 (SD 46): 41.2cm3 (3 cases) in patients with no diagnosis; 33.6cm3 (232 cases, SD 47) in patients with specific diagnosis; and 36.6cm3 (76 cases, SD 44) in patients with descriptive diagnosis. Biopsy volume had no influence on histopathology yield (ANOVA, p value 0.8). Conclusions: The number and volume of the biopsy specimens in SLB did not seem to influence diagnosis. Based on our results, we believe a single sample from a representative area may be sufficient for diagnosis. Randomized prospective trials should be performed to optimize SLB for ILD.",
keywords = "Diagnostic yield, Interstitial lung disease, Surgical lung biopsy",
author = "Fibla, {Juan J.} and Alessandro Brunelli and Allen, {Mark S.} and Wigle, {Dennis A} and Robert Shen and Francis Nichols and Claude Deschamps and Cassivi, {Stephen D.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.arbres.2014.05.011",
language = "Spanish",
volume = "51",
pages = "76--79",
journal = "Archivos de Bronconeumologia",
issn = "0300-2896",
publisher = "Ediciones Doyma, S.L.",
number = "2",

}

TY - JOUR

T1 - ¿Influyen el número y volumen de las biopsias pulmonares en el rendimiento diagnóstico en la enfermedad pulmonar intersticial? Análisis mediante índice de propensión

AU - Fibla, Juan J.

AU - Brunelli, Alessandro

AU - Allen, Mark S.

AU - Wigle, Dennis A

AU - Shen, Robert

AU - Nichols, Francis

AU - Deschamps, Claude

AU - Cassivi, Stephen D.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Introduction: Our objective was to evaluate whether the number and volume of surgical lung biopsies (SLB) influence the diagnosis of diffuse interstitial lung disease (ILD). Methods: Retrospective study of SLB for suspected ILD in patients from the Mayo Clinic from January 2002 to January 2010. Data were collected in the institution and analyzed. Results: 311 patients were studied. Mean number of biopsies was 2.05 (SD 0.6); 1 biopsy in 50 (16%), 2 in 198 (63.7%), 3 in 59 (19%) and 4 in 4 (1.3%). Histopathologic diagnosis was: definitive (specific): 232 (74.6%), descriptive (non-specific): 76 (24.4%), no diagnosis: 3 (1%). After excluding patients without diagnosis (n=3), there were 50 patients with only 1 biopsy, 196 with 2 and 62 with 3 or 4; the definitive diagnostic yield was similar in all 3 groups (37/50; 74%, 150/196; 77%, and 45/62; 73%) (Chi-square, p value 0.8). The propensity score analysis between patients with 1 SLB and patients with more than 1 SLB also showed no difference in diagnostic yield. Regarding the volume of biopsies, mean total volume was 34.4cm3 (SD 46): 41.2cm3 (3 cases) in patients with no diagnosis; 33.6cm3 (232 cases, SD 47) in patients with specific diagnosis; and 36.6cm3 (76 cases, SD 44) in patients with descriptive diagnosis. Biopsy volume had no influence on histopathology yield (ANOVA, p value 0.8). Conclusions: The number and volume of the biopsy specimens in SLB did not seem to influence diagnosis. Based on our results, we believe a single sample from a representative area may be sufficient for diagnosis. Randomized prospective trials should be performed to optimize SLB for ILD.

AB - Introduction: Our objective was to evaluate whether the number and volume of surgical lung biopsies (SLB) influence the diagnosis of diffuse interstitial lung disease (ILD). Methods: Retrospective study of SLB for suspected ILD in patients from the Mayo Clinic from January 2002 to January 2010. Data were collected in the institution and analyzed. Results: 311 patients were studied. Mean number of biopsies was 2.05 (SD 0.6); 1 biopsy in 50 (16%), 2 in 198 (63.7%), 3 in 59 (19%) and 4 in 4 (1.3%). Histopathologic diagnosis was: definitive (specific): 232 (74.6%), descriptive (non-specific): 76 (24.4%), no diagnosis: 3 (1%). After excluding patients without diagnosis (n=3), there were 50 patients with only 1 biopsy, 196 with 2 and 62 with 3 or 4; the definitive diagnostic yield was similar in all 3 groups (37/50; 74%, 150/196; 77%, and 45/62; 73%) (Chi-square, p value 0.8). The propensity score analysis between patients with 1 SLB and patients with more than 1 SLB also showed no difference in diagnostic yield. Regarding the volume of biopsies, mean total volume was 34.4cm3 (SD 46): 41.2cm3 (3 cases) in patients with no diagnosis; 33.6cm3 (232 cases, SD 47) in patients with specific diagnosis; and 36.6cm3 (76 cases, SD 44) in patients with descriptive diagnosis. Biopsy volume had no influence on histopathology yield (ANOVA, p value 0.8). Conclusions: The number and volume of the biopsy specimens in SLB did not seem to influence diagnosis. Based on our results, we believe a single sample from a representative area may be sufficient for diagnosis. Randomized prospective trials should be performed to optimize SLB for ILD.

KW - Diagnostic yield

KW - Interstitial lung disease

KW - Surgical lung biopsy

UR - http://www.scopus.com/inward/record.url?scp=84921604422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921604422&partnerID=8YFLogxK

U2 - 10.1016/j.arbres.2014.05.011

DO - 10.1016/j.arbres.2014.05.011

M3 - Article

C2 - 25308724

AN - SCOPUS:84921604422

VL - 51

SP - 76

EP - 79

JO - Archivos de Bronconeumologia

JF - Archivos de Bronconeumologia

SN - 0300-2896

IS - 2

ER -