¿Influyen el número y volumen de las biopsias pulmonares en el rendimiento diagnóstico en la enfermedad pulmonar intersticial? Análisis mediante índice de propensión

Translated title of the contribution: Do the number and volume of surgical lung biopsies influence the diagnostic yield in interstitial lung disease? A propensity score analysis

Juan J. Fibla, Alessandro Brunelli, Mark S. Allen, Dennis Wigle, Robert Shen, Francis Nichols, Claude Deschamps, Stephen D. Cassivi

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Introduction: Our objective was to evaluate whether the number and volume of surgical lung biopsies (SLB) influence the diagnosis of diffuse interstitial lung disease (ILD). Methods: Retrospective study of SLB for suspected ILD in patients from the Mayo Clinic from January 2002 to January 2010. Data were collected in the institution and analyzed. Results: 311 patients were studied. Mean number of biopsies was 2.05 (SD 0.6); 1 biopsy in 50 (16%), 2 in 198 (63.7%), 3 in 59 (19%) and 4 in 4 (1.3%). Histopathologic diagnosis was: definitive (specific): 232 (74.6%), descriptive (non-specific): 76 (24.4%), no diagnosis: 3 (1%). After excluding patients without diagnosis (n=3), there were 50 patients with only 1 biopsy, 196 with 2 and 62 with 3 or 4; the definitive diagnostic yield was similar in all 3 groups (37/50; 74%, 150/196; 77%, and 45/62; 73%) (Chi-square, p value 0.8). The propensity score analysis between patients with 1 SLB and patients with more than 1 SLB also showed no difference in diagnostic yield. Regarding the volume of biopsies, mean total volume was 34.4cm3 (SD 46): 41.2cm3 (3 cases) in patients with no diagnosis; 33.6cm3 (232 cases, SD 47) in patients with specific diagnosis; and 36.6cm3 (76 cases, SD 44) in patients with descriptive diagnosis. Biopsy volume had no influence on histopathology yield (ANOVA, p value 0.8). Conclusions: The number and volume of the biopsy specimens in SLB did not seem to influence diagnosis. Based on our results, we believe a single sample from a representative area may be sufficient for diagnosis. Randomized prospective trials should be performed to optimize SLB for ILD.

Translated title of the contributionDo the number and volume of surgical lung biopsies influence the diagnostic yield in interstitial lung disease? A propensity score analysis
Original languageSpanish
Pages (from-to)76-79
Number of pages4
JournalArchivos de Bronconeumologia
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Diagnostic yield
  • Interstitial lung disease
  • Surgical lung biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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