Do rheumatoid arthritis patients have a higher risk for sleep apnea?

Stephanie R. Reading, Cynthia Crowson, Richard J. Rodeheffer, Patrick D. Fitz-Gibbon, Hilal D Maradit Kremers, Sherine E. Gabriel

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective. Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular disease (CVD) compared to subjects in the general population. The development of CVD has also been linked to chronic sleep apnea. The purpose of this study was to examine the risk for sleep apnea in patients with RA compared to subjects without RA. Methods. We recruited RA patients and non-RA subjects who were age and sex matched from the same population. These persons completed the Berlin Sleep Questionnaire, which evaluated their level of risk (high or low) for sleep apnea. In addition, there were 3 subscales evaluating snoring, fatigue, and relevant comorbidities [i.e., high blood pressure and obesity [body mass index (BMI) ≥ 30 kg/m2)]. Chi-squared tests were used for comparisons. Results. The study population consisted of 164 patients with RA and 328 patients without RA. Age, sex and BMI were similar for both groups. There was no difference in snoring (p = 0.31) or in the comorbidities subscale (p = 0.37). However, RA patients reported more fatigue (38%) than subjects without RA (13%; p < 0.001). Overall, the risk for sleep apnea was significantly higher for the RA patients (50%) than the non-RA subjects (31%; p < 0.001). Conclusion. Patients with RA may be at a higher risk for sleep apnea compared to non-RA subjects. This apparent risk difference may be attributed to reports of fatigue in RA patients, which may be associated with sleep apnea or RA disease itself. The Journal of Rheumatology

Original languageEnglish (US)
Pages (from-to)1869-1872
Number of pages4
JournalJournal of Rheumatology
Volume36
Issue number9
DOIs
StatePublished - Sep 2009

Fingerprint

Sleep Apnea Syndromes
Rheumatoid Arthritis
Arthritis
Fatigue
Snoring
Comorbidity
Body Mass Index
Cardiovascular Diseases
Population
Rheumatology
Berlin
Sleep
Obesity
Hypertension

Keywords

  • Cardiovascular disease
  • Rheumatoid arthritis
  • Sleep apnea

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Do rheumatoid arthritis patients have a higher risk for sleep apnea? / Reading, Stephanie R.; Crowson, Cynthia; Rodeheffer, Richard J.; Fitz-Gibbon, Patrick D.; Maradit Kremers, Hilal D; Gabriel, Sherine E.

In: Journal of Rheumatology, Vol. 36, No. 9, 09.2009, p. 1869-1872.

Research output: Contribution to journalArticle

Reading, Stephanie R. ; Crowson, Cynthia ; Rodeheffer, Richard J. ; Fitz-Gibbon, Patrick D. ; Maradit Kremers, Hilal D ; Gabriel, Sherine E. / Do rheumatoid arthritis patients have a higher risk for sleep apnea?. In: Journal of Rheumatology. 2009 ; Vol. 36, No. 9. pp. 1869-1872.
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abstract = "Objective. Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular disease (CVD) compared to subjects in the general population. The development of CVD has also been linked to chronic sleep apnea. The purpose of this study was to examine the risk for sleep apnea in patients with RA compared to subjects without RA. Methods. We recruited RA patients and non-RA subjects who were age and sex matched from the same population. These persons completed the Berlin Sleep Questionnaire, which evaluated their level of risk (high or low) for sleep apnea. In addition, there were 3 subscales evaluating snoring, fatigue, and relevant comorbidities [i.e., high blood pressure and obesity [body mass index (BMI) ≥ 30 kg/m2)]. Chi-squared tests were used for comparisons. Results. The study population consisted of 164 patients with RA and 328 patients without RA. Age, sex and BMI were similar for both groups. There was no difference in snoring (p = 0.31) or in the comorbidities subscale (p = 0.37). However, RA patients reported more fatigue (38{\%}) than subjects without RA (13{\%}; p < 0.001). Overall, the risk for sleep apnea was significantly higher for the RA patients (50{\%}) than the non-RA subjects (31{\%}; p < 0.001). Conclusion. Patients with RA may be at a higher risk for sleep apnea compared to non-RA subjects. This apparent risk difference may be attributed to reports of fatigue in RA patients, which may be associated with sleep apnea or RA disease itself. The Journal of Rheumatology",
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N2 - Objective. Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular disease (CVD) compared to subjects in the general population. The development of CVD has also been linked to chronic sleep apnea. The purpose of this study was to examine the risk for sleep apnea in patients with RA compared to subjects without RA. Methods. We recruited RA patients and non-RA subjects who were age and sex matched from the same population. These persons completed the Berlin Sleep Questionnaire, which evaluated their level of risk (high or low) for sleep apnea. In addition, there were 3 subscales evaluating snoring, fatigue, and relevant comorbidities [i.e., high blood pressure and obesity [body mass index (BMI) ≥ 30 kg/m2)]. Chi-squared tests were used for comparisons. Results. The study population consisted of 164 patients with RA and 328 patients without RA. Age, sex and BMI were similar for both groups. There was no difference in snoring (p = 0.31) or in the comorbidities subscale (p = 0.37). However, RA patients reported more fatigue (38%) than subjects without RA (13%; p < 0.001). Overall, the risk for sleep apnea was significantly higher for the RA patients (50%) than the non-RA subjects (31%; p < 0.001). Conclusion. Patients with RA may be at a higher risk for sleep apnea compared to non-RA subjects. This apparent risk difference may be attributed to reports of fatigue in RA patients, which may be associated with sleep apnea or RA disease itself. The Journal of Rheumatology

AB - Objective. Patients with rheumatoid arthritis (RA) have an increased risk for developing cardiovascular disease (CVD) compared to subjects in the general population. The development of CVD has also been linked to chronic sleep apnea. The purpose of this study was to examine the risk for sleep apnea in patients with RA compared to subjects without RA. Methods. We recruited RA patients and non-RA subjects who were age and sex matched from the same population. These persons completed the Berlin Sleep Questionnaire, which evaluated their level of risk (high or low) for sleep apnea. In addition, there were 3 subscales evaluating snoring, fatigue, and relevant comorbidities [i.e., high blood pressure and obesity [body mass index (BMI) ≥ 30 kg/m2)]. Chi-squared tests were used for comparisons. Results. The study population consisted of 164 patients with RA and 328 patients without RA. Age, sex and BMI were similar for both groups. There was no difference in snoring (p = 0.31) or in the comorbidities subscale (p = 0.37). However, RA patients reported more fatigue (38%) than subjects without RA (13%; p < 0.001). Overall, the risk for sleep apnea was significantly higher for the RA patients (50%) than the non-RA subjects (31%; p < 0.001). Conclusion. Patients with RA may be at a higher risk for sleep apnea compared to non-RA subjects. This apparent risk difference may be attributed to reports of fatigue in RA patients, which may be associated with sleep apnea or RA disease itself. The Journal of Rheumatology

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