Do Not Assume Symptoms Indicate Failure of Anti-Tumor Necrosis Factor Therapy in Crohn's Disease

David H. Bruining, William J. Sandborn

Research output: Contribution to journalArticle

18 Scopus citations


It is a challenge to monitor patients with Crohn's disease who remain symptomatic despite anti-tumor necrosis factor therapy. Clinicians must use a systematic approach for each patient and obtain objective evidence about disease activity and response to therapy. Alternate etiologies for symptoms should be sought and treated, if found. Active Crohn's disease despite therapy requires reassessment and adjustments to management plans.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalClinical Gastroenterology and Hepatology
Issue number5
StatePublished - May 1 2011



  • Anti-TNF Therapy
  • Crohn's Disease
  • Treatment Failure

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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