Do medications affect outcomes in pelvic pouch construction?

Amy L. Lightner

Research output: Contribution to journalArticlepeer-review


Ileal pouch anal anastomosis is the preferred operation for restoration of intestinal continuity in patients with ulcerative colitis due to favorable functional outcomes and quality of life. However, up to 30% can develop postoperative complications, of which pelvic sepsis is the most dreaded due to impaired pouch function and increased rates of pouch failure. Several modifiable risk factors are associated with postoperative pelvic sepsis including obesity, poor nutritional status, anemia, and immunosuppressive therapy. While the evidence regarding the effect of immunosuppressive therapy on adverse postoperative outcomes is controversial, there is mounting data to suggest the operation performed at the time of immunosuppression exposure is critical for subsequent pouch outcomes. This has resulted in an increased number of pouches being performed as a modified 2-stage or 3-stage approach, a conservative yet safe approach to avoid potential deleterious effects of immunosuppression at the critical step of pouch formation.

Original languageEnglish (US)
Pages (from-to)2-6
Number of pages5
JournalSeminars in Colon and Rectal Surgery
Issue number1
StatePublished - Mar 2019


  • Biologics
  • Ileal pouch anal anastomosis
  • Immunosuppression
  • Pelvic sepsis
  • Ulcerative colitis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


Dive into the research topics of 'Do medications affect outcomes in pelvic pouch construction?'. Together they form a unique fingerprint.

Cite this