Do cold agglutinins have any impact on the outcome of liver transplantation?

Willem A. Marsman, S. Breanndan Moore, Mario Kondo, Kevin L. Bundy, Gregory James Gores, Russell H. Wiesner, Ruud A F Krom

Research output: Contribution to journalArticle

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Abstract

Cold agglutinins, IgM red blood cell autoantibodies, cause cold agglutinin disease with hemolysis and microvascular occlusion. Cold preservation of kidneys during renal transplantation in the presence of cold agglutinins can cause graft malfunction. However, the impact of cold agglutinins on the outcome of liver transplantation is unknown. We measured the pretransplant presence and titer of cold agglutinins in 327 primary liver allograft recipients and analyzed their relationship to outcome after transplant. Thirty-three percent of pretransplant patients had cold agglutinins. Cold agglutinins were more common in patients with viral- related liver diseases (49%) compared with those with nonviral-related liver disease (32%). There was no difference between recipients with and without cold agglutinins in usage of blood products, postoperative day 2 aminotransferase levels, acute rejection at day 7, the development of hepatic artery thrombosis, nonanastomotic biliary strictures, or 4-month allograft survival. In conclusion, cold agglutinins are common in liver transplant patients before surgery, especially those with viral-related liver diseases. However, the presence of cold agglutinins does not impact on outcome after liver transplantation.

Original languageEnglish (US)
Pages (from-to)1673-1676
Number of pages4
JournalTransplantation
Volume62
Issue number11
DOIs
StatePublished - Dec 15 1996

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Liver Transplantation
Liver Diseases
Transplants
Allografts
cold agglutinins
Autoimmune Hemolytic Anemia
Liver
Hepatic Artery
Hemolysis
Transaminases
Autoantibodies
Kidney Transplantation
Immunoglobulin M
Pathologic Constriction
Thrombosis
Erythrocytes
Kidney

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Marsman, W. A., Moore, S. B., Kondo, M., Bundy, K. L., Gores, G. J., Wiesner, R. H., & Krom, R. A. F. (1996). Do cold agglutinins have any impact on the outcome of liver transplantation? Transplantation, 62(11), 1673-1676. https://doi.org/10.1097/00007890-199612150-00025

Do cold agglutinins have any impact on the outcome of liver transplantation? / Marsman, Willem A.; Moore, S. Breanndan; Kondo, Mario; Bundy, Kevin L.; Gores, Gregory James; Wiesner, Russell H.; Krom, Ruud A F.

In: Transplantation, Vol. 62, No. 11, 15.12.1996, p. 1673-1676.

Research output: Contribution to journalArticle

Marsman, WA, Moore, SB, Kondo, M, Bundy, KL, Gores, GJ, Wiesner, RH & Krom, RAF 1996, 'Do cold agglutinins have any impact on the outcome of liver transplantation?', Transplantation, vol. 62, no. 11, pp. 1673-1676. https://doi.org/10.1097/00007890-199612150-00025
Marsman, Willem A. ; Moore, S. Breanndan ; Kondo, Mario ; Bundy, Kevin L. ; Gores, Gregory James ; Wiesner, Russell H. ; Krom, Ruud A F. / Do cold agglutinins have any impact on the outcome of liver transplantation?. In: Transplantation. 1996 ; Vol. 62, No. 11. pp. 1673-1676.
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