DNMT1 knockout delivers a strong blow to genome stability and cell viability

Kevin D. Brown, Keith D Robertson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

Original languageEnglish (US)
Pages (from-to)289-290
Number of pages2
JournalNature Genetics
Volume39
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Genomic Instability
Cell Survival
Gene Targeting
Methyltransferases
Genome
DNA
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

DNMT1 knockout delivers a strong blow to genome stability and cell viability. / Brown, Kevin D.; Robertson, Keith D.

In: Nature Genetics, Vol. 39, No. 3, 03.2007, p. 289-290.

Research output: Contribution to journalArticle

@article{c680e4d43b994ca8bdbad1ee967bfaa7,
title = "DNMT1 knockout delivers a strong blow to genome stability and cell viability",
abstract = "The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.",
author = "Brown, {Kevin D.} and Robertson, {Keith D}",
year = "2007",
month = "3",
doi = "10.1038/ng0307-289",
language = "English (US)",
volume = "39",
pages = "289--290",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - DNMT1 knockout delivers a strong blow to genome stability and cell viability

AU - Brown, Kevin D.

AU - Robertson, Keith D

PY - 2007/3

Y1 - 2007/3

N2 - The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

AB - The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

UR - http://www.scopus.com/inward/record.url?scp=33847250332&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847250332&partnerID=8YFLogxK

U2 - 10.1038/ng0307-289

DO - 10.1038/ng0307-289

M3 - Article

C2 - 17325677

AN - SCOPUS:33847250332

VL - 39

SP - 289

EP - 290

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -