DNMT1 knockout delivers a strong blow to genome stability and cell viability

Kevin D. Brown, Keith D. Robertson

Research output: Contribution to journalShort survey

39 Scopus citations

Abstract

The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.

Original languageEnglish (US)
Pages (from-to)289-290
Number of pages2
JournalNature Genetics
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2007

ASJC Scopus subject areas

  • Genetics

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