Abstract
The DNA methyltransferase DNMT1 is essential for cell viability in various mouse models, but gene targeting in human tumor cells results in a viable line. This dilemma has now been resolved using a new human DNMT1 knockout line, although new questions arise as to the full extent of DNMT1 function in maintaining genome integrity.
Original language | English (US) |
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Pages (from-to) | 289-290 |
Number of pages | 2 |
Journal | Nature Genetics |
Volume | 39 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2007 |
ASJC Scopus subject areas
- Genetics