DNA pooling as a tool for large-scale association studies in complex traits

Nadine Norton, Nigel M. Williams, Michael C. O'Donovan, Michael J. Owen

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalAnnals of Medicine
Volume36
Issue number2
DOIs
StatePublished - 2004

Keywords

  • Association
  • Complex traits
  • DNA pooling
  • SNP

ASJC Scopus subject areas

  • Medicine(all)

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