DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma

Thomas E. Witzig, Charles L. Loprinzi, Nick J. Gonchoroff, Herbert M. Reiman, Steven S. Cha, H. Sam Wieand, Jerry A. Katzmann, J. Kevin Paulsen, Charles G. Moertel

Research output: Contribution to journalArticlepeer-review

160 Scopus citations

Abstract

DNA content and cell proliferation were measured by flow cytometry on paraffinembedded Stage B2 or C colorectal adenocarcinomas from 694 patients enrolled in adjuvant trials conducted by the North Central Cancer Treatment Group. Patients with diploid tumors had a higher survival rate than those with nondiploid tumors (P < 0.001). The proliferation index (the sum of the percent of cells in S‐phase plus those in G2M phase) was also a strong prognostic factor (P < 0.001). The ploidy and proliferation data were combined, and the patients in the favorable group (diploid and low proliferative index) had a 5‐year survival of 74% compared with 54% for the unfavorable group (high proliferative index or nondiploid, P < 0.001). This grouping was prognostic for survival in B2 (P < 0.001), C (P = 0.013), colon (P < 0.001), and rectal (P = 0.026) patient subsets. This study indicates that cell kinetic parameters are important and independent prognostic factors for Stages B2 and C colorectal cancer.

Original languageEnglish (US)
Pages (from-to)879-888
Number of pages10
JournalCancer
Volume68
Issue number4
DOIs
StatePublished - Aug 15 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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