DNA methylation and the Epstein-Barr virus

Richard F. Ambinder, Keith D Robertson, Qian Tao

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

EBV is a ubiquitous herpesvirus associated with a variety of lymphoid and epithelial tumors. In healthy lymphocytes and in tumors immune surveillance is evaded by suppression of a family of immunodeficient viral antigens. Methylation of a viral promoter plays a crucial role in this suppression. Methylation of the viral genome in the latent state over evolutionary time is believed to account for CpG suppression that distinguishes this virus from most other large DNA viruses. Pharmacologic manipulation of methylation may offer an opportunity to unmask viral antigens and expose tumors to immense surveillance.

Original languageEnglish (US)
Pages (from-to)369-375
Number of pages7
JournalSeminars in Cancer Biology
Volume9
Issue number5
DOIs
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

DNA Methylation
Human Herpesvirus 4
Methylation
DNA Viruses
Viral Antigens
Viral Genome
Herpesviridae
Viral Tumor Antigens
Neoplasms
Lymphocytes
Viruses

Keywords

  • Burkitts lymphoma
  • EBNA
  • Epstein-Barr virus
  • Hodgkin's disease
  • Methylation
  • Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Cancer Research

Cite this

DNA methylation and the Epstein-Barr virus. / Ambinder, Richard F.; Robertson, Keith D; Tao, Qian.

In: Seminars in Cancer Biology, Vol. 9, No. 5, 10.1999, p. 369-375.

Research output: Contribution to journalArticle

Ambinder, Richard F. ; Robertson, Keith D ; Tao, Qian. / DNA methylation and the Epstein-Barr virus. In: Seminars in Cancer Biology. 1999 ; Vol. 9, No. 5. pp. 369-375.
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