DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. These include embryonic development, transcription, chromatin structure, X chromosome inactivation, genomic imprinting and chromosome stability. Consistent with these important roles, a growing number of human diseases have been found to be associated with aberrant DNA methylation. The study of these diseases has provided new and fundamental insights into the roles that DNA methylation and other epigenetic modifications have in development and normal cellular homeostasis.
|Original language||English (US)|
|Number of pages||14|
|Journal||Nature Reviews Genetics|
|State||Published - Aug 2005|
ASJC Scopus subject areas
- Molecular Biology