DNA methylation and human disease

Research output: Contribution to journalArticle

1605 Citations (Scopus)

Abstract

DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. These include embryonic development, transcription, chromatin structure, X chromosome inactivation, genomic imprinting and chromosome stability. Consistent with these important roles, a growing number of human diseases have been found to be associated with aberrant DNA methylation. The study of these diseases has provided new and fundamental insights into the roles that DNA methylation and other epigenetic modifications have in development and normal cellular homeostasis.

Original languageEnglish (US)
Pages (from-to)597-610
Number of pages14
JournalNature Reviews Genetics
Volume6
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

DNA methylation
DNA Methylation
human diseases
Epigenomics
epigenetics
Genomic Imprinting
X Chromosome Inactivation
Chromosomal Instability
genomic imprinting
Genomic Instability
X chromosome
Chromatin
Embryonic Development
chromatin
homeostasis
inactivation
Homeostasis
embryogenesis
transcription (genetics)
Genome

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

DNA methylation and human disease. / Robertson, Keith D.

In: Nature Reviews Genetics, Vol. 6, No. 8, 08.2005, p. 597-610.

Research output: Contribution to journalArticle

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