DNA methylation and human disease

Keith D. Robertson

doi:10.1038/nrg1655

DNA methylation and human disease

Keith D. Robertson

Pharmacology

Research output: Contribution to journal › Review article › peer-review

1837 Scopus citations

Abstract

DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. These include embryonic development, transcription, chromatin structure, X chromosome inactivation, genomic imprinting and chromosome stability. Consistent with these important roles, a growing number of human diseases have been found to be associated with aberrant DNA methylation. The study of these diseases has provided new and fundamental insights into the roles that DNA methylation and other epigenetic modifications have in development and normal cellular homeostasis.

Original language	English (US)
Pages (from-to)	597-610
Number of pages	14
Journal	Nature Reviews Genetics
Volume	6
Issue number	8
DOIs	https://doi.org/10.1038/nrg1655
State	Published - Aug 2005

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1038/nrg1655

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DNA methylation and human disease

Abstract

ASJC Scopus subject areas

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