DNA methylation, age-related immune defects, and autoimmunity

Jörg J. Goronzy, Guangjin Li, Cornelia M. Weyand

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The adaptive immune system is a highly proliferative organ that combines ongoing differentiation with preservation of memory. CpG DNA methylation is central to many of the fate decisions that occur from early lymphoid development to late effector functions of end-differentiated cells. Many of the DNA demethylation-sensitive genes play an important role in autoimmune diseases and in the immune defects that are associated with the aging process, suggesting that failing epigenetic control mechanisms of genes involved in adaptive immune responses contribute to these diseases.

Original languageEnglish (US)
Title of host publicationEpigenetics of Aging
PublisherSpringer New York
Pages327-344
Number of pages18
ISBN (Electronic)9781441906397
ISBN (Print)9781441906380
DOIs
StatePublished - 2010

Keywords

  • Aging
  • Epigenetics
  • Immune senescence
  • T cells

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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