DNA methylation age is accelerated in alcohol dependence

Allison D. Rosen, Keith D Robertson, Ryan A. Hlady, Christine Muench, Jisoo Lee, Robert Philibert, Steve Horvath, Zachary A. Kaminsky, Falk W. Lohoff

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature deaths each year. Previous research suggests that chronic, heavy alcohol consumption is associated with differential DNA methylation patterns. In addition, DNA methylation levels at certain CpG sites have been correlated with age. We used an epigenetic clock to investigate the potential role of excessive alcohol consumption in epigenetic aging. We explored this question in five independent cohorts, including DNA methylation data derived from datasets from blood (n = 129, n = 329), liver (n = 92, n = 49), and postmortem prefrontal cortex (n = 46). One blood dataset and one liver tissue dataset of individuals with ALC exhibited positive age acceleration (p < 0.0001 and p = 0.0069, respectively), whereas the other blood and liver tissue datasets both exhibited trends of positive age acceleration that were not significant (p = 0.83 and p = 0.57, respectively). Prefrontal cortex tissue exhibited a trend of negative age acceleration (p = 0.19). These results suggest that excessive alcohol consumption may be associated with epigenetic aging in a tissue-specific manner and warrants further investigation using multiple tissue samples from the same individuals.

Original languageEnglish (US)
Article number182
JournalTranslational Psychiatry
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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DNA Methylation
Alcoholism
Epigenomics
Alcohol Drinking
Prefrontal Cortex
Liver
Premature Mortality
Chronic Disease
Datasets
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

Cite this

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., ... Lohoff, F. W. (2018). DNA methylation age is accelerated in alcohol dependence. Translational Psychiatry, 8(1), [182]. https://doi.org/10.1038/s41398-018-0233-4

DNA methylation age is accelerated in alcohol dependence. / Rosen, Allison D.; Robertson, Keith D; Hlady, Ryan A.; Muench, Christine; Lee, Jisoo; Philibert, Robert; Horvath, Steve; Kaminsky, Zachary A.; Lohoff, Falk W.

In: Translational Psychiatry, Vol. 8, No. 1, 182, 01.12.2018.

Research output: Contribution to journalArticle

Rosen, AD, Robertson, KD, Hlady, RA, Muench, C, Lee, J, Philibert, R, Horvath, S, Kaminsky, ZA & Lohoff, FW 2018, 'DNA methylation age is accelerated in alcohol dependence', Translational Psychiatry, vol. 8, no. 1, 182. https://doi.org/10.1038/s41398-018-0233-4
Rosen, Allison D. ; Robertson, Keith D ; Hlady, Ryan A. ; Muench, Christine ; Lee, Jisoo ; Philibert, Robert ; Horvath, Steve ; Kaminsky, Zachary A. ; Lohoff, Falk W. / DNA methylation age is accelerated in alcohol dependence. In: Translational Psychiatry. 2018 ; Vol. 8, No. 1.
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