TY - JOUR
T1 - Diverse roles of neurotensin agonists in the central nervous system
AU - Boules, Mona
AU - Li, Zhimin
AU - Smith, Kristin
AU - Fredrickson, Paul
AU - Richelson, Elliott
PY - 2013
Y1 - 2013
N2 - Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic, and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson's disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and PD.
AB - Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic, and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson's disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and PD.
KW - Central nervous system
KW - Endocrinology
KW - Neurotensin
KW - Pain
KW - Psychostimulant abuse
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84884189750&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884189750&partnerID=8YFLogxK
U2 - 10.3389/fendo.2013.00036
DO - 10.3389/fendo.2013.00036
M3 - Review article
C2 - 23526754
AN - SCOPUS:84884189750
SN - 1664-2392
VL - 4
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - MAR
M1 - Article 36
ER -