TY - JOUR
T1 - Divergent effects of cyproheptadine and R 50 656, A 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats
AU - Krstić, Milovan K.
AU - Katušić, Zvonimir S.
PY - 1982/11/19
Y1 - 1982/11/19
N2 - Cyproheptadine and R 50 656, a novel 5-HT2 antagonist, produced a dose-dependent supression of the pressor response to 5-hydroxytryptamine (5-HT), but did not affect the depressor response. The pressor effect of 5-HT was significantly more sensitive to R 50 656 than to cyproheptadine. On the contrary, the tachycardic response to 5-HT was antagonized only with cryproheptadine. Accordingly, in rats the 5-HT receptors of cardiac tissue differ in their pharmacological properties from both the excitatory and inhibitory 5-HT receptors of vascular smooth muscle.
AB - Cyproheptadine and R 50 656, a novel 5-HT2 antagonist, produced a dose-dependent supression of the pressor response to 5-hydroxytryptamine (5-HT), but did not affect the depressor response. The pressor effect of 5-HT was significantly more sensitive to R 50 656 than to cyproheptadine. On the contrary, the tachycardic response to 5-HT was antagonized only with cryproheptadine. Accordingly, in rats the 5-HT receptors of cardiac tissue differ in their pharmacological properties from both the excitatory and inhibitory 5-HT receptors of vascular smooth muscle.
KW - 5-HT receptors
KW - 5-Hydroxytryptamine
KW - Cardiovascular response
KW - Cyproheptadine
KW - R 50 656
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U2 - 10.1016/0014-2999(82)90471-X
DO - 10.1016/0014-2999(82)90471-X
M3 - Article
C2 - 6129985
AN - SCOPUS:0020385882
SN - 0014-2999
VL - 85
SP - 225
EP - 227
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -