Divergent effects of cyproheptadine and R 50 656, A 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats

Milovan K. Krstić, Zvonimir S. Katušić

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Cyproheptadine and R 50 656, a novel 5-HT2 antagonist, produced a dose-dependent supression of the pressor response to 5-hydroxytryptamine (5-HT), but did not affect the depressor response. The pressor effect of 5-HT was significantly more sensitive to R 50 656 than to cyproheptadine. On the contrary, the tachycardic response to 5-HT was antagonized only with cryproheptadine. Accordingly, in rats the 5-HT receptors of cardiac tissue differ in their pharmacological properties from both the excitatory and inhibitory 5-HT receptors of vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)225-227
Number of pages3
JournalEuropean Journal of Pharmacology
Volume85
Issue number2
DOIs
StatePublished - Nov 19 1982

Keywords

  • 5-HT receptors
  • 5-Hydroxytryptamine
  • Cardiovascular response
  • Cyproheptadine
  • R 50 656

ASJC Scopus subject areas

  • Pharmacology

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