Divergent effects of a designer natriuretic peptide CD-NP in the regulation of adipose tissue and metabolism

Anja Glöde, Jennifer Naumann, Thorsten Gnad, Valentina Cannone, Ana Kilic, John C Jr. Burnett, Alexander Pfeifer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease. Brown adipose tissue (BAT) dissipates energy and correlates with leanness. Natriuretic peptides have been shown to be beneficial for brown adipocyte differentiation and browning of WAT. Methods Here, we investigated the effects of an optimized designer natriuretic peptide (CD-NP) on murine adipose tissues in vitro and in vivo. Results In murine brown and white adipocytes, CD-NP activated cGMP production, promoted adipogenesis, and increased thermogenic markers. Consequently, mice treated for 10 days with CD-NP exhibited increased “browning” of WAT. To study CD-NP effects on diet-induced obesity (DIO), we delivered CD-NP for 12 weeks. Although CD-NP reduced inflammation in WAT, CD-NP treated DIO mice exhibited a significant increase in body mass, worsened glucose tolerance, and hepatic steatosis. Long-term CD-NP treatment resulted in an increased expression of the NP scavenging receptor (NPR-C) and decreased lipolytic activity. Conclusions NP effects differed depending on the duration of treatment raising questions about the rational of natriuretic peptide treatment in obese patients.

Original languageEnglish (US)
Pages (from-to)276-287
Number of pages12
JournalMolecular Metabolism
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • Adipocytes
  • Browning
  • cGMP
  • Diet-induced obesity
  • Natriuretic peptides

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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