Diuretic renal scintigraphy in patients with sulfonamide allergies: Possible alternative use of ethacrynic acid

Ba D. Nguyen; Michael C. Roarke; Jason Robert Young; Ming Yang; Howard H. Osborn

doi:10.2967/jnmt.115.161331

Diuretic renal scintigraphy in patients with sulfonamide allergies: Possible alternative use of ethacrynic acid

Ba D. Nguyen, Michael C. Roarke, Jason Robert Young, Ming Yang, Howard H. Osborn

Diagnostic Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Furosemide may trigger life-threatening sulfonamide crosshypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.

Original language	English (US)
Pages (from-to)	239-241
Number of pages	3
Journal	Journal of nuclear medicine technology
Volume	43
Issue number	4
DOIs	https://doi.org/10.2967/jnmt.115.161331
State	Published - 2015

Keywords

Diuretic renal scintigraphy
Ethacrynic acid
Sulfonamide allergy

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.2967/jnmt.115.161331

Cite this

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title = "Diuretic renal scintigraphy in patients with sulfonamide allergies: Possible alternative use of ethacrynic acid",

abstract = "Furosemide may trigger life-threatening sulfonamide crosshypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.",

keywords = "Diuretic renal scintigraphy, Ethacrynic acid, Sulfonamide allergy",

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T1 - Diuretic renal scintigraphy in patients with sulfonamide allergies

T2 - Possible alternative use of ethacrynic acid

AU - Nguyen, Ba D.

AU - Roarke, Michael C.

AU - Young, Jason Robert

AU - Yang, Ming

AU - Osborn, Howard H.

PY - 2015

Y1 - 2015

N2 - Furosemide may trigger life-threatening sulfonamide crosshypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.

AB - Furosemide may trigger life-threatening sulfonamide crosshypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.

KW - Diuretic renal scintigraphy

KW - Ethacrynic acid

KW - Sulfonamide allergy

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Diuretic renal scintigraphy in patients with sulfonamide allergies: Possible alternative use of ethacrynic acid

Abstract

Keywords

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