Disulfiram Treatment of Patients with Both Alcohol Dependence and Other Psychiatric Disorders: A Review

Eric W. Larson, Ann Olincy, Teresa A. Rummans, Robert M. Morse

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

In treatment of alcohol dependence, disulfiram is most useful in conjunction with a structured, supervised, aftercare program. However, it has been reported to cause psychiatric side effects and to interact with various psychiatric medications. Many patients with alcohol dependence suffer from other psychiatric disorders and are treated with such psychiatric medications. This paper reviews the pertinent clinical pharmacology of disulfiram and the literature on potential psychiatric complications and drug interactions of disulfiram. At the usual dosage, about 250 mg/day, disulfiram does not appear to increase significantly the risk of psychiatric complications or of psychiatric drug interactions. Therefore, it can be considered a treatment option for patients with alcohol dependence and other psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • Alcohol Dependence
  • Disulfiram
  • Drug Interactions
  • Dual Disorders
  • Organic Mental Disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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