Distribution of proneuropeptide Y‐derived peptides in the brain of Rana esculenta and Xenopus laevis

Gyula Lázár, Jerome L. Maderdrut, Scott L. Trasti, Zsolt Liposits, Pál Tóth, Tamás Kozicz, István Merchenthaler

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

The distribution ofproneuropeptide Y‐containing perikarya and nerve fibers in the brain of Rana esculenta and Xenopus lavis was determined with antisera directed toward neuropeptide Y and the carboxyl terminal flanking peptide. The distribution of proneuropeptide Y‐like immunoreactivity was similar in both anurans. In the telencephalon, immunoreactive perikarya were found in the olfactory bulb, all subdivisions of the pallium, the septum, pars lateralis of the amygdala, the nucleus accumbens, and the anterior preoptic area. In the diencephalon, labelled perikarya were detected in the ventromedial, ventrolateral and central thalamic nuclei, the magnocellular preoptic nucleus, the suprachiasmatic nucleus, the posterior tuberculum, and the infundibulum. Amacrine‐like cells were stained in the retina. In the pretectal area, posterior thalamic neurons showed intense, Golgi‐like immunostaining. In the mesencephalon, immunoreactive cells were found in the reticular nucleus, the anteroventral tegmental nucleus, the optic tectum, the interpeduncular nucleus, and the torus semicircularis. In the rhombencephalon, labelled perikarya were detected in the secondary visceral nucleus, the central gray, the nucleus of the solitary tract, the dorsal column nuclei, and the spinal nucleus of the trigeminal nerve. Immunoreactive nerve fibers were observed in all areas of the brain that contained labelled perikarya. The densest accumulations were found in the accessory olfactory bulb, pars lateralis of the amygdala, the ventral habenula, the posterior pituitary, the optic tectum, the interpeduncular nucleus, and the saccular nucleus. The distribution of proneuropeptide Y‐like immunoreactivity in the anuran brain showed many similarities to the distribution described for the amniote brain. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)551-571
Number of pages21
JournalJournal of Comparative Neurology
Volume327
Issue number4
DOIs
StatePublished - Jan 22 1993

Keywords

  • amphibia
  • electron microscopy
  • evolution
  • hypothalamus
  • immunocytochemistry
  • neuroanatomy
  • neuropeptide Y
  • optic tectum
  • pancreatic polypeptide

ASJC Scopus subject areas

  • Neuroscience(all)

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