Distribution of infecting hepatitis C virus genotypes in end-stage liver disease patients at a large American Transplantation Center

H. E. Vargas, L. F. Wang, T. Laskus, A. Poutous, R. Lee, A. Demetris, F. Dodson, A. Casavilla, J. Fung, T. Gayowski, N. Singh, I. Marino, J. Rakela

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The distribution of hepatitis C virus (HCV) genotypes was studied in 202 anti-HCV-positive liver transplant candidates with end-stage liver disease. HCV sequences were successfully amplified from 185 patients: In the first 100, the genotype was determined by direct sequencing in the NS5 region, and in the remaining 85, type-specific primers were used for genotyping. Eighty- five patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%) with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5 (2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type 2c. Thirteen HCV-positive patients (7.0%) could not be genotyped. The relatively low prevalence of genotype 1b in this population of end-stage liver disease patients speaks against postulated higher pathogenicity of this genotype.

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalJournal of Infectious Diseases
Volume175
Issue number2
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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