TY - JOUR
T1 - Distribution of infecting hepatitis C virus genotypes in end-stage liver disease patients at a large American Transplantation Center
AU - Vargas, H. E.
AU - Wang, L. F.
AU - Laskus, T.
AU - Poutous, A.
AU - Lee, R.
AU - Demetris, A.
AU - Dodson, F.
AU - Casavilla, A.
AU - Fung, J.
AU - Gayowski, T.
AU - Singh, N.
AU - Marino, I.
AU - Rakela, J.
PY - 1997
Y1 - 1997
N2 - The distribution of hepatitis C virus (HCV) genotypes was studied in 202 anti-HCV-positive liver transplant candidates with end-stage liver disease. HCV sequences were successfully amplified from 185 patients: In the first 100, the genotype was determined by direct sequencing in the NS5 region, and in the remaining 85, type-specific primers were used for genotyping. Eighty- five patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%) with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5 (2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type 2c. Thirteen HCV-positive patients (7.0%) could not be genotyped. The relatively low prevalence of genotype 1b in this population of end-stage liver disease patients speaks against postulated higher pathogenicity of this genotype.
AB - The distribution of hepatitis C virus (HCV) genotypes was studied in 202 anti-HCV-positive liver transplant candidates with end-stage liver disease. HCV sequences were successfully amplified from 185 patients: In the first 100, the genotype was determined by direct sequencing in the NS5 region, and in the remaining 85, type-specific primers were used for genotyping. Eighty- five patients (46.0%) were infected with type 1a HCV strains, 52 (28.1%) with type 1b, 14 (7.6%) with type 2b, 13 (7.0%) with type 4, 5 (2.7%) with type 3a, 2 (1.1%) with type 2a, and 1 (0.5%) with type 2c. Thirteen HCV-positive patients (7.0%) could not be genotyped. The relatively low prevalence of genotype 1b in this population of end-stage liver disease patients speaks against postulated higher pathogenicity of this genotype.
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U2 - 10.1093/infdis/175.2.448
DO - 10.1093/infdis/175.2.448
M3 - Article
C2 - 9203670
AN - SCOPUS:0031036401
SN - 0022-1899
VL - 175
SP - 448
EP - 450
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -