Distribution of endothelin-1 in transplanted human lungs

Anders Jeppsson, Henry D. Tazelaar, Virginia M Miller, Christopher G A Mcgregor

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background. This study was designed to assess which cells in transplanted lungs express endothelin-1 (ET-1) and if expression of the peptide can be used to discriminate between rejection and infection in transplanted lungs. Methods. Transbronchial biopsies (n-104) from 29 burnan lung transplant recipients were stained immunohistochemically for ET-1. Cells expressing ET-1 (pneumocytes, endothelial cells, airway epithelial cells, lymphocytes, and macrophages) were quantified and correlated with clinical histopathology findings. Results. ET-1 was expressed in airway epithelial cells (93% of the biopsies), infiltrating macrophages (86%), and lymphocytes (19%) but not in endothelial cells or pneumocytes. ET-1 expression did not vary with rejection, obliterative bronchiolitis, or infection. ET-1 expression did not correlate with age, grade of rejection, pulmonary function, or time after transplantation. Conclusion. In transplanted human lungs, ET-1 is expressed in airway epithelial cells and infiltrating macrophages, and expression does not vary with pathological processes. Therefore, immnunostaining for ET-1 probably cannot be used to discriminate between rejection and infection in transplanted lungs.

Original languageEnglish (US)
Pages (from-to)806-809
Number of pages4
JournalTransplantation
Volume66
Issue number6
DOIs
StatePublished - Sep 27 1998

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Endothelin-1
Lung
Alveolar Epithelial Cells
Epithelial Cells
Macrophages
Endothelial Cells
Infection
Lymphocytes
Biopsy
Bronchiolitis
Pathologic Processes
Transplantation
Peptides

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Distribution of endothelin-1 in transplanted human lungs. / Jeppsson, Anders; Tazelaar, Henry D.; Miller, Virginia M; Mcgregor, Christopher G A.

In: Transplantation, Vol. 66, No. 6, 27.09.1998, p. 806-809.

Research output: Contribution to journalArticle

Jeppsson, Anders ; Tazelaar, Henry D. ; Miller, Virginia M ; Mcgregor, Christopher G A. / Distribution of endothelin-1 in transplanted human lungs. In: Transplantation. 1998 ; Vol. 66, No. 6. pp. 806-809.
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