Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men

Thomas Rhodes, Debra J. Jacobson, Michaela E. McGree, Jennifer St. Sauver, Aruna V. Sarma, Cynthia J. Girman, Michael M. Lieber, George G. Klee, Kitaw Demissie, Steven J. Jacobsen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: We provide cross-sectional normative data on [-2]proenzyme- prostate specific antigen from the Olmsted County Study of Urinary Symptoms and Health Status among Men, and the Flint Men's Health Study. We also describe associations with clinical urological measures and the risk of prostate cancer diagnosis. Materials and Methods: Measurements of [-2]proenzyme-prostate specific antigen were obtained from 420 white men from Olmsted County, Minnesota, and 328 black men from Genesee County, Michigan. Cross-sectional associations between [-2]proenzyme-prostate specific antigen and prostate enlargement/elevated prostate specific antigen were assessed. Cox proportional hazard models were used to assess associations between [-2]proenzyme-prostate specific antigen and the incident diagnosis of prostate cancer. Results: Baseline [-2]proenzyme-prostate specific antigen was slightly higher in black men at a median of 6.3 pg/ml (25th, 75th percentiles 4.1, 8.9) than in white men at a median of 5.6 pg/ml (25th, 75th percentiles 3.9, 7.7, respectively, p = 0.01). Baseline [-2]proenzyme-prostate specific antigen was highly predictive of biopsy confirmed prostate cancer in the Olmsted County Study cohort. Relative to men in the [-2]proenzyme-prostate specific antigen lower quartile those in the upper quartile were at almost eightfold increased risk for prostate cancer (HR 7.8, 95% CI 2.2-27.8) after adjusting for age and baseline prostate specific antigen. Conclusions: In these cohorts of community dwelling black and white men [-2]proenzyme-prostate specific antigen was much lower than in previous studies. These data suggest that [-2]proenzyme-prostate specific antigen may help identify prostate cancer in men with serum prostate specific antigen in an indeterminate range, although the reference ranges for white and black men may differ slightly.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalJournal of Urology
Volume187
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Independent Living
Enzyme Precursors
Prostate-Specific Antigen
Prostatic Neoplasms
hydroquinone
Men's Health
Proportional Hazards Models
Health Status
Prostate
Reference Values

Keywords

  • enzyme precursors
  • prostate
  • prostate-specific antigen
  • prostatic hyperplasia
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men. / Rhodes, Thomas; Jacobson, Debra J.; McGree, Michaela E.; St. Sauver, Jennifer; Sarma, Aruna V.; Girman, Cynthia J.; Lieber, Michael M.; Klee, George G.; Demissie, Kitaw; Jacobsen, Steven J.

In: Journal of Urology, Vol. 187, No. 1, 01.2012, p. 92-96.

Research output: Contribution to journalArticle

Rhodes, T, Jacobson, DJ, McGree, ME, St. Sauver, J, Sarma, AV, Girman, CJ, Lieber, MM, Klee, GG, Demissie, K & Jacobsen, SJ 2012, 'Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men', Journal of Urology, vol. 187, no. 1, pp. 92-96. https://doi.org/10.1016/j.juro.2011.09.060
Rhodes, Thomas ; Jacobson, Debra J. ; McGree, Michaela E. ; St. Sauver, Jennifer ; Sarma, Aruna V. ; Girman, Cynthia J. ; Lieber, Michael M. ; Klee, George G. ; Demissie, Kitaw ; Jacobsen, Steven J. / Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men. In: Journal of Urology. 2012 ; Vol. 187, No. 1. pp. 92-96.
@article{2dbcbf044a3248ad909317e1715be5b4,
title = "Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men",
abstract = "Purpose: We provide cross-sectional normative data on [-2]proenzyme- prostate specific antigen from the Olmsted County Study of Urinary Symptoms and Health Status among Men, and the Flint Men's Health Study. We also describe associations with clinical urological measures and the risk of prostate cancer diagnosis. Materials and Methods: Measurements of [-2]proenzyme-prostate specific antigen were obtained from 420 white men from Olmsted County, Minnesota, and 328 black men from Genesee County, Michigan. Cross-sectional associations between [-2]proenzyme-prostate specific antigen and prostate enlargement/elevated prostate specific antigen were assessed. Cox proportional hazard models were used to assess associations between [-2]proenzyme-prostate specific antigen and the incident diagnosis of prostate cancer. Results: Baseline [-2]proenzyme-prostate specific antigen was slightly higher in black men at a median of 6.3 pg/ml (25th, 75th percentiles 4.1, 8.9) than in white men at a median of 5.6 pg/ml (25th, 75th percentiles 3.9, 7.7, respectively, p = 0.01). Baseline [-2]proenzyme-prostate specific antigen was highly predictive of biopsy confirmed prostate cancer in the Olmsted County Study cohort. Relative to men in the [-2]proenzyme-prostate specific antigen lower quartile those in the upper quartile were at almost eightfold increased risk for prostate cancer (HR 7.8, 95{\%} CI 2.2-27.8) after adjusting for age and baseline prostate specific antigen. Conclusions: In these cohorts of community dwelling black and white men [-2]proenzyme-prostate specific antigen was much lower than in previous studies. These data suggest that [-2]proenzyme-prostate specific antigen may help identify prostate cancer in men with serum prostate specific antigen in an indeterminate range, although the reference ranges for white and black men may differ slightly.",
keywords = "enzyme precursors, prostate, prostate-specific antigen, prostatic hyperplasia, prostatic neoplasms",
author = "Thomas Rhodes and Jacobson, {Debra J.} and McGree, {Michaela E.} and {St. Sauver}, Jennifer and Sarma, {Aruna V.} and Girman, {Cynthia J.} and Lieber, {Michael M.} and Klee, {George G.} and Kitaw Demissie and Jacobsen, {Steven J.}",
year = "2012",
month = "1",
doi = "10.1016/j.juro.2011.09.060",
language = "English (US)",
volume = "187",
pages = "92--96",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Distribution and Associations of [-2]Proenzyme-Prostate Specific Antigen in Community Dwelling Black and White Men

AU - Rhodes, Thomas

AU - Jacobson, Debra J.

AU - McGree, Michaela E.

AU - St. Sauver, Jennifer

AU - Sarma, Aruna V.

AU - Girman, Cynthia J.

AU - Lieber, Michael M.

AU - Klee, George G.

AU - Demissie, Kitaw

AU - Jacobsen, Steven J.

PY - 2012/1

Y1 - 2012/1

N2 - Purpose: We provide cross-sectional normative data on [-2]proenzyme- prostate specific antigen from the Olmsted County Study of Urinary Symptoms and Health Status among Men, and the Flint Men's Health Study. We also describe associations with clinical urological measures and the risk of prostate cancer diagnosis. Materials and Methods: Measurements of [-2]proenzyme-prostate specific antigen were obtained from 420 white men from Olmsted County, Minnesota, and 328 black men from Genesee County, Michigan. Cross-sectional associations between [-2]proenzyme-prostate specific antigen and prostate enlargement/elevated prostate specific antigen were assessed. Cox proportional hazard models were used to assess associations between [-2]proenzyme-prostate specific antigen and the incident diagnosis of prostate cancer. Results: Baseline [-2]proenzyme-prostate specific antigen was slightly higher in black men at a median of 6.3 pg/ml (25th, 75th percentiles 4.1, 8.9) than in white men at a median of 5.6 pg/ml (25th, 75th percentiles 3.9, 7.7, respectively, p = 0.01). Baseline [-2]proenzyme-prostate specific antigen was highly predictive of biopsy confirmed prostate cancer in the Olmsted County Study cohort. Relative to men in the [-2]proenzyme-prostate specific antigen lower quartile those in the upper quartile were at almost eightfold increased risk for prostate cancer (HR 7.8, 95% CI 2.2-27.8) after adjusting for age and baseline prostate specific antigen. Conclusions: In these cohorts of community dwelling black and white men [-2]proenzyme-prostate specific antigen was much lower than in previous studies. These data suggest that [-2]proenzyme-prostate specific antigen may help identify prostate cancer in men with serum prostate specific antigen in an indeterminate range, although the reference ranges for white and black men may differ slightly.

AB - Purpose: We provide cross-sectional normative data on [-2]proenzyme- prostate specific antigen from the Olmsted County Study of Urinary Symptoms and Health Status among Men, and the Flint Men's Health Study. We also describe associations with clinical urological measures and the risk of prostate cancer diagnosis. Materials and Methods: Measurements of [-2]proenzyme-prostate specific antigen were obtained from 420 white men from Olmsted County, Minnesota, and 328 black men from Genesee County, Michigan. Cross-sectional associations between [-2]proenzyme-prostate specific antigen and prostate enlargement/elevated prostate specific antigen were assessed. Cox proportional hazard models were used to assess associations between [-2]proenzyme-prostate specific antigen and the incident diagnosis of prostate cancer. Results: Baseline [-2]proenzyme-prostate specific antigen was slightly higher in black men at a median of 6.3 pg/ml (25th, 75th percentiles 4.1, 8.9) than in white men at a median of 5.6 pg/ml (25th, 75th percentiles 3.9, 7.7, respectively, p = 0.01). Baseline [-2]proenzyme-prostate specific antigen was highly predictive of biopsy confirmed prostate cancer in the Olmsted County Study cohort. Relative to men in the [-2]proenzyme-prostate specific antigen lower quartile those in the upper quartile were at almost eightfold increased risk for prostate cancer (HR 7.8, 95% CI 2.2-27.8) after adjusting for age and baseline prostate specific antigen. Conclusions: In these cohorts of community dwelling black and white men [-2]proenzyme-prostate specific antigen was much lower than in previous studies. These data suggest that [-2]proenzyme-prostate specific antigen may help identify prostate cancer in men with serum prostate specific antigen in an indeterminate range, although the reference ranges for white and black men may differ slightly.

KW - enzyme precursors

KW - prostate

KW - prostate-specific antigen

KW - prostatic hyperplasia

KW - prostatic neoplasms

UR - http://www.scopus.com/inward/record.url?scp=83555162514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83555162514&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2011.09.060

DO - 10.1016/j.juro.2011.09.060

M3 - Article

C2 - 22093189

AN - SCOPUS:83555162514

VL - 187

SP - 92

EP - 96

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -