Abstract
High-frequency microsatellite instability (MSI-H) accounts for roughly 15 % of all cases of colorectal cancer (CRC) and results from pathogenic mutations or epigenetic changes in mismatch repair (MMR) proteins, primarily MLH1, MSH2, MSH6, and PMS2. These alterations can be inherited, as in the case of Lynch syndrome, or can be acquired sporadically, including cases of epigenetic alteration along crucial regulatory sequences. Cancers that develop in the setting of MSI-H possess a unique clinicopathologic phenotype, with a high degree of mutation resulting in potential recognition by the immune system. These features have directed therapeutic investigation in recent years to involve consideration of immune-stimulating agents, which might exploit the inherent immunogenicity of these tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-287 |
| Number of pages | 7 |
| Journal | Current Colorectal Cancer Reports |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jul 23 2015 |
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Keywords
- Chromosomal instability
- Colorectal cancer
- Microsatellite instability
- Mismatch repair deficiency
ASJC Scopus subject areas
- Oncology
- Gastroenterology
- Hepatology
Cite this
Distinctive Tumor Biology of MSI-High Colorectal Cancer. / Majithia, Neil; Kipp, Benjamin R.; Grothey, Axel F.
In: Current Colorectal Cancer Reports, Vol. 11, No. 5, 23.07.2015, p. 281-287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distinctive Tumor Biology of MSI-High Colorectal Cancer
AU - Majithia, Neil
AU - Kipp, Benjamin R.
AU - Grothey, Axel F
PY - 2015/7/23
Y1 - 2015/7/23
N2 - High-frequency microsatellite instability (MSI-H) accounts for roughly 15 % of all cases of colorectal cancer (CRC) and results from pathogenic mutations or epigenetic changes in mismatch repair (MMR) proteins, primarily MLH1, MSH2, MSH6, and PMS2. These alterations can be inherited, as in the case of Lynch syndrome, or can be acquired sporadically, including cases of epigenetic alteration along crucial regulatory sequences. Cancers that develop in the setting of MSI-H possess a unique clinicopathologic phenotype, with a high degree of mutation resulting in potential recognition by the immune system. These features have directed therapeutic investigation in recent years to involve consideration of immune-stimulating agents, which might exploit the inherent immunogenicity of these tumors.
AB - High-frequency microsatellite instability (MSI-H) accounts for roughly 15 % of all cases of colorectal cancer (CRC) and results from pathogenic mutations or epigenetic changes in mismatch repair (MMR) proteins, primarily MLH1, MSH2, MSH6, and PMS2. These alterations can be inherited, as in the case of Lynch syndrome, or can be acquired sporadically, including cases of epigenetic alteration along crucial regulatory sequences. Cancers that develop in the setting of MSI-H possess a unique clinicopathologic phenotype, with a high degree of mutation resulting in potential recognition by the immune system. These features have directed therapeutic investigation in recent years to involve consideration of immune-stimulating agents, which might exploit the inherent immunogenicity of these tumors.
KW - Chromosomal instability
KW - Colorectal cancer
KW - Microsatellite instability
KW - Mismatch repair deficiency
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UR - http://www.scopus.com/inward/citedby.url?scp=84940452530&partnerID=8YFLogxK
U2 - 10.1007/s11888-015-0283-4
DO - 10.1007/s11888-015-0283-4
M3 - Article
AN - SCOPUS:84940452530
VL - 11
SP - 281
EP - 287
JO - Current Colorectal Cancer Reports
JF - Current Colorectal Cancer Reports
SN - 1556-3790
IS - 5
ER -