TY - JOUR
T1 - Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias
AU - Possin, Katherine L.
AU - Feigenbaum, Dana
AU - Rankin, Katherine P.
AU - Smith, Glenn E.
AU - Boxer, Adam L.
AU - Wood, Kristie
AU - Hanna, Sherrie M.
AU - Miller, Bruce L.
AU - Kramer, Joel H.
PY - 2013/6/11
Y1 - 2013/6/11
N2 - Objective: The objective of this study was to determine which aspects of executive functions are most affected in behavioral variant frontotemporal dementia (bvFTD) and best differentiate this syndrome from Alzheimer disease (AD). Methods: We compared executive functions in 22 patients diagnosed with bvFTD, 26 with AD, and 31 neurologically healthy controls using a conceptually driven and comprehensive battery of executive function tests, the NIH EXAMINER battery (http://examiner.ucsf.edu). Results: The bvFTD and the AD patients were similarly impaired compared with controls on tests of working memory, category fluency, and attention, but the patients with bvFTD showed significantly more severe impairments than the patients with AD on tests of letter fluency, antisaccade accuracy, social decision-making, and social behavior. Discriminant function analysis with jackknifed cross-validation classified the bvFTD and AD patient groups with 73% accuracy. Conclusions: Executive function assessment can support bvFTD diagnosis when measures are carefully selected to emphasize frontally specific functions. Neurology® 2013;80:2180-2185
AB - Objective: The objective of this study was to determine which aspects of executive functions are most affected in behavioral variant frontotemporal dementia (bvFTD) and best differentiate this syndrome from Alzheimer disease (AD). Methods: We compared executive functions in 22 patients diagnosed with bvFTD, 26 with AD, and 31 neurologically healthy controls using a conceptually driven and comprehensive battery of executive function tests, the NIH EXAMINER battery (http://examiner.ucsf.edu). Results: The bvFTD and the AD patients were similarly impaired compared with controls on tests of working memory, category fluency, and attention, but the patients with bvFTD showed significantly more severe impairments than the patients with AD on tests of letter fluency, antisaccade accuracy, social decision-making, and social behavior. Discriminant function analysis with jackknifed cross-validation classified the bvFTD and AD patient groups with 73% accuracy. Conclusions: Executive function assessment can support bvFTD diagnosis when measures are carefully selected to emphasize frontally specific functions. Neurology® 2013;80:2180-2185
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U2 - 10.1212/WNL.0b013e318296e940
DO - 10.1212/WNL.0b013e318296e940
M3 - Article
C2 - 23658382
AN - SCOPUS:84879083375
SN - 0028-3878
VL - 80
SP - 2180
EP - 2185
JO - Neurology
JF - Neurology
IS - 24
ER -