Abstract
Both solid and hematologic malignancies may be complicated by coagulopathies. Disseminated intravascular coagulation (DIC) in the presence of pancreatic cancer is generally unrecognized and may have fatal consequences. The diagnosis of DIC in a patient with advanced cancer is a poor prognostic indicator. Presented here is a case study consisting of two patients presenting with a new diagnosis of pancreatic cancer complicated by DIC. Aggressive supportive treatment in addition to systemic chemotherapy consisting of gemcitabine and nabpaclitaxel was initiated and DIC was controlled. An early diagnosis of DIC and the administration of systemic chemotherapy with a high response rate and an ability to reduce tumor bulk rapidly may offer some patients the probability of recovery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 266-269 |
| Number of pages | 4 |
| Journal | Oncology (Switzerland) |
| Volume | 87 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 19 2014 |
| Externally published | Yes |
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Keywords
- Advanced pancreatic cancer
- Combination chemotherapy
- Disseminated intravascular coagulation
ASJC Scopus subject areas
- Medicine(all)
- Oncology
- Cancer Research
Cite this
Disseminated intravascular coagulation secondary to advanced pancreatic cancer treated successfully with combination chemotherapy. / Mast, Cathy; Ramanathan, Ramesk K; Feinstein, Donald I.; Rosen, Peter.
In: Oncology (Switzerland), Vol. 87, No. 5, 19.11.2014, p. 266-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disseminated intravascular coagulation secondary to advanced pancreatic cancer treated successfully with combination chemotherapy
AU - Mast, Cathy
AU - Ramanathan, Ramesk K
AU - Feinstein, Donald I.
AU - Rosen, Peter
PY - 2014/11/19
Y1 - 2014/11/19
N2 - Both solid and hematologic malignancies may be complicated by coagulopathies. Disseminated intravascular coagulation (DIC) in the presence of pancreatic cancer is generally unrecognized and may have fatal consequences. The diagnosis of DIC in a patient with advanced cancer is a poor prognostic indicator. Presented here is a case study consisting of two patients presenting with a new diagnosis of pancreatic cancer complicated by DIC. Aggressive supportive treatment in addition to systemic chemotherapy consisting of gemcitabine and nabpaclitaxel was initiated and DIC was controlled. An early diagnosis of DIC and the administration of systemic chemotherapy with a high response rate and an ability to reduce tumor bulk rapidly may offer some patients the probability of recovery.
AB - Both solid and hematologic malignancies may be complicated by coagulopathies. Disseminated intravascular coagulation (DIC) in the presence of pancreatic cancer is generally unrecognized and may have fatal consequences. The diagnosis of DIC in a patient with advanced cancer is a poor prognostic indicator. Presented here is a case study consisting of two patients presenting with a new diagnosis of pancreatic cancer complicated by DIC. Aggressive supportive treatment in addition to systemic chemotherapy consisting of gemcitabine and nabpaclitaxel was initiated and DIC was controlled. An early diagnosis of DIC and the administration of systemic chemotherapy with a high response rate and an ability to reduce tumor bulk rapidly may offer some patients the probability of recovery.
KW - Advanced pancreatic cancer
KW - Combination chemotherapy
KW - Disseminated intravascular coagulation
UR - http://www.scopus.com/inward/record.url?scp=84906020006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906020006&partnerID=8YFLogxK
U2 - 10.1159/000365552
DO - 10.1159/000365552
M3 - Article
C2 - 25139314
AN - SCOPUS:84906020006
VL - 87
SP - 266
EP - 269
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 5
ER -