Disseminated High-grade Glioma in a Long-term Survivor of Medulloblastoma

Implications and Management of Radiation-induced Malignancies

Research output: Contribution to journalArticle

Abstract

We describe a gentleman diagnosed with a posterior fossa medulloblastoma in 1998, successfully treated with craniospinal radiation therapy (RT) and posterior fossa RT boost, followed by 12 months of adjuvant chemotherapy. Nineteen years later, at the age of 28, the patient presented with multiple cranial neuropathies and was found to have disseminated high-grade glioma with leptomeningeal dissemination. In addition to the salient features of this case, we provide a brief review of RT-induced malignancies and the need for further research regarding surveillance and prevention strategies.

Original languageEnglish (US)
Pages (from-to)191-193
Number of pages3
JournalNeurologist
Volume23
Issue number6
DOIs
StatePublished - Nov 1 2018

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Medulloblastoma
Glioma
Survivors
Radiotherapy
Radiation
Cranial Nerve Diseases
Neoplasms
Adjuvant Chemotherapy
Research

Keywords

  • glioma
  • Medulloblastoma
  • radiation-induced malignancy

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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title = "Disseminated High-grade Glioma in a Long-term Survivor of Medulloblastoma: Implications and Management of Radiation-induced Malignancies",
abstract = "We describe a gentleman diagnosed with a posterior fossa medulloblastoma in 1998, successfully treated with craniospinal radiation therapy (RT) and posterior fossa RT boost, followed by 12 months of adjuvant chemotherapy. Nineteen years later, at the age of 28, the patient presented with multiple cranial neuropathies and was found to have disseminated high-grade glioma with leptomeningeal dissemination. In addition to the salient features of this case, we provide a brief review of RT-induced malignancies and the need for further research regarding surveillance and prevention strategies.",
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author = "{Porter Umphrey}, {Alyx B} and Sio, {Terence T.} and Nelson, {Kent D.} and Aditya Raghunathan and Bernard Bendok and Maciej Mrugala",
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AU - Sio, Terence T.

AU - Nelson, Kent D.

AU - Raghunathan, Aditya

AU - Bendok, Bernard

AU - Mrugala, Maciej

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AB - We describe a gentleman diagnosed with a posterior fossa medulloblastoma in 1998, successfully treated with craniospinal radiation therapy (RT) and posterior fossa RT boost, followed by 12 months of adjuvant chemotherapy. Nineteen years later, at the age of 28, the patient presented with multiple cranial neuropathies and was found to have disseminated high-grade glioma with leptomeningeal dissemination. In addition to the salient features of this case, we provide a brief review of RT-induced malignancies and the need for further research regarding surveillance and prevention strategies.

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