Disseminated aspergillosis involving the brain: Distribution and imaging characteristics

David R. DeLone, Ross A. Goldstein, Greg Petermann, M. Shahriar Salamat, Janet M. Miles, Stuart J. Knechtle, W. Douglas Brown

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate its early diagnosis. METHODS: The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neuroradiologists. The studies were evaluated for anatomic distribution of lesions, signal characteristics of lesions, enhancement, hemorrhage, and progression on serial studies (when performed). Medical records, biopsy reports, and autopsy findings were reviewed. RESULTS: Thirteen of 18 patients had involvement of the basal nuclei and/or thalami. Nine of the 10 patients with lesions at the corticomedullary junction also had lesions in the basal nuclei or thalami. Callosal lesions were seen in seven patients. Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed. Enhancement was minimal or absent in most cases. There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three. CONCLUSION: Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction. Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospective diagnosis.

Original languageEnglish (US)
Pages (from-to)1597-1604
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume20
Issue number9
StatePublished - 1999
Externally publishedYes

Fingerprint

Aspergillosis
Neuroimaging
Hemorrhage
Basal Ganglia
Thalamus
Autopsy
Biopsy
Corpus Callosum
Brain
Aspergillus
Medical Records
Early Diagnosis
Arteries
Infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

DeLone, D. R., Goldstein, R. A., Petermann, G., Salamat, M. S., Miles, J. M., Knechtle, S. J., & Brown, W. D. (1999). Disseminated aspergillosis involving the brain: Distribution and imaging characteristics. American Journal of Neuroradiology, 20(9), 1597-1604.

Disseminated aspergillosis involving the brain : Distribution and imaging characteristics. / DeLone, David R.; Goldstein, Ross A.; Petermann, Greg; Salamat, M. Shahriar; Miles, Janet M.; Knechtle, Stuart J.; Brown, W. Douglas.

In: American Journal of Neuroradiology, Vol. 20, No. 9, 1999, p. 1597-1604.

Research output: Contribution to journalArticle

DeLone, DR, Goldstein, RA, Petermann, G, Salamat, MS, Miles, JM, Knechtle, SJ & Brown, WD 1999, 'Disseminated aspergillosis involving the brain: Distribution and imaging characteristics', American Journal of Neuroradiology, vol. 20, no. 9, pp. 1597-1604.
DeLone DR, Goldstein RA, Petermann G, Salamat MS, Miles JM, Knechtle SJ et al. Disseminated aspergillosis involving the brain: Distribution and imaging characteristics. American Journal of Neuroradiology. 1999;20(9):1597-1604.
DeLone, David R. ; Goldstein, Ross A. ; Petermann, Greg ; Salamat, M. Shahriar ; Miles, Janet M. ; Knechtle, Stuart J. ; Brown, W. Douglas. / Disseminated aspergillosis involving the brain : Distribution and imaging characteristics. In: American Journal of Neuroradiology. 1999 ; Vol. 20, No. 9. pp. 1597-1604.
@article{85e04975d70b436ca1a6fb927228fed1,
title = "Disseminated aspergillosis involving the brain: Distribution and imaging characteristics",
abstract = "BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate its early diagnosis. METHODS: The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neuroradiologists. The studies were evaluated for anatomic distribution of lesions, signal characteristics of lesions, enhancement, hemorrhage, and progression on serial studies (when performed). Medical records, biopsy reports, and autopsy findings were reviewed. RESULTS: Thirteen of 18 patients had involvement of the basal nuclei and/or thalami. Nine of the 10 patients with lesions at the corticomedullary junction also had lesions in the basal nuclei or thalami. Callosal lesions were seen in seven patients. Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed. Enhancement was minimal or absent in most cases. There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three. CONCLUSION: Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction. Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospective diagnosis.",
author = "DeLone, {David R.} and Goldstein, {Ross A.} and Greg Petermann and Salamat, {M. Shahriar} and Miles, {Janet M.} and Knechtle, {Stuart J.} and Brown, {W. Douglas}",
year = "1999",
language = "English (US)",
volume = "20",
pages = "1597--1604",
journal = "American Journal of Neuroradiology",
issn = "0195-6108",
publisher = "American Society of Neuroradiology",
number = "9",

}

TY - JOUR

T1 - Disseminated aspergillosis involving the brain

T2 - Distribution and imaging characteristics

AU - DeLone, David R.

AU - Goldstein, Ross A.

AU - Petermann, Greg

AU - Salamat, M. Shahriar

AU - Miles, Janet M.

AU - Knechtle, Stuart J.

AU - Brown, W. Douglas

PY - 1999

Y1 - 1999

N2 - BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate its early diagnosis. METHODS: The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neuroradiologists. The studies were evaluated for anatomic distribution of lesions, signal characteristics of lesions, enhancement, hemorrhage, and progression on serial studies (when performed). Medical records, biopsy reports, and autopsy findings were reviewed. RESULTS: Thirteen of 18 patients had involvement of the basal nuclei and/or thalami. Nine of the 10 patients with lesions at the corticomedullary junction also had lesions in the basal nuclei or thalami. Callosal lesions were seen in seven patients. Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed. Enhancement was minimal or absent in most cases. There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three. CONCLUSION: Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction. Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospective diagnosis.

AB - BACKGROUND AND PURPOSE: Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate its early diagnosis. METHODS: The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neuroradiologists. The studies were evaluated for anatomic distribution of lesions, signal characteristics of lesions, enhancement, hemorrhage, and progression on serial studies (when performed). Medical records, biopsy reports, and autopsy findings were reviewed. RESULTS: Thirteen of 18 patients had involvement of the basal nuclei and/or thalami. Nine of the 10 patients with lesions at the corticomedullary junction also had lesions in the basal nuclei or thalami. Callosal lesions were seen in seven patients. Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed. Enhancement was minimal or absent in most cases. There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three. CONCLUSION: Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction. Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospective diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=0032755964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032755964&partnerID=8YFLogxK

M3 - Article

C2 - 10543627

AN - SCOPUS:0032755964

VL - 20

SP - 1597

EP - 1604

JO - American Journal of Neuroradiology

JF - American Journal of Neuroradiology

SN - 0195-6108

IS - 9

ER -