Dissecting molecular mechanisms in bile acid diarrhea

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Abstract

It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone - fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and 75 SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with 75 SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.

Original languageEnglish (US)
Pages (from-to)433-435
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume111
Issue number3
DOIs
StatePublished - Mar 1 2016

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ASJC Scopus subject areas

  • Gastroenterology

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