Abstract
It was previously demonstrated that patients with bile acid (BA) diarrhea have low fasting serum levels of the ileal hormone - fibroblast growth factor-19 (FGF-19). In this paper, the authors demonstrate a positive correlation between ileal transcripts of FGF-19 and 75 SeHCAT retention, providing further evidence of FGF-19 deficiency as an explanation for BA diarrhea. Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with 75 SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.
Original language | English (US) |
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Pages (from-to) | 433-435 |
Number of pages | 3 |
Journal | American Journal of Gastroenterology |
Volume | 111 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2016 |
ASJC Scopus subject areas
- Hepatology
- Gastroenterology