Disruption of the perineurium in amphibian peripheral nerve: Morphology and physiology

T. L. Pencek, C. L. Schauf, Phillip Anson Low, B. R. Eisenberg, F. A. Davis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Removal of a small piece of perineurium in amphibian nerve causes a lesion consistent with the presence of extensive demyelination. Conduction velocity is reduced by 30 to 40%, and most of the fibers that still conduct are labile, with abnormally low blocking temperatures and unusual susceptibility to conduction block induced by changes in extracellular electrolytes. Application of drugs that inhibit the delayed K + conductance restores conduction to fibers blocked by temperature elevation and ionic changes. This preparation may prove useful in studies of the pathophysiology of demyelinating diseases.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalNeurology
Volume30
Issue number6
StatePublished - 1980

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Demyelinating Diseases
Amphibians
Peripheral Nerves
Temperature
Electrolytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pencek, T. L., Schauf, C. L., Low, P. A., Eisenberg, B. R., & Davis, F. A. (1980). Disruption of the perineurium in amphibian peripheral nerve: Morphology and physiology. Neurology, 30(6), 593-599.

Disruption of the perineurium in amphibian peripheral nerve : Morphology and physiology. / Pencek, T. L.; Schauf, C. L.; Low, Phillip Anson; Eisenberg, B. R.; Davis, F. A.

In: Neurology, Vol. 30, No. 6, 1980, p. 593-599.

Research output: Contribution to journalArticle

Pencek, TL, Schauf, CL, Low, PA, Eisenberg, BR & Davis, FA 1980, 'Disruption of the perineurium in amphibian peripheral nerve: Morphology and physiology', Neurology, vol. 30, no. 6, pp. 593-599.
Pencek TL, Schauf CL, Low PA, Eisenberg BR, Davis FA. Disruption of the perineurium in amphibian peripheral nerve: Morphology and physiology. Neurology. 1980;30(6):593-599.
Pencek, T. L. ; Schauf, C. L. ; Low, Phillip Anson ; Eisenberg, B. R. ; Davis, F. A. / Disruption of the perineurium in amphibian peripheral nerve : Morphology and physiology. In: Neurology. 1980 ; Vol. 30, No. 6. pp. 593-599.
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