Disparities in treatment and survival for women with endometrial cancer: A contemporary national cancer database registry analysis

Amanda N. Fader, Elizabeth B Habermann, Kristine T. Hanson, Jeff F. Lin, Edward C. Grendys, Sean Christopher Dowdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The study aim was to identify contemporary socioeconomic, racial, ethnic, and facility-related factors associated with stage at diagnosis, receipt of cancer treatment, and survival in women with endometrial cancer (EC). Patients and methods: Women diagnosed with EC between 1998 and 2010 were identified from the National Cancer Database. Variables associated with the outcomes of interest were assessed using multivariable Cox proportional hazards and logistic regression. Results: Among 228,511 women identified, the percentage of blacks with stage IIIC/IV disease at diagnosis was nearly twice that of non-Hispanic whites (17.8% vs 9.8%; . P . <. 0.001). Patients with advanced disease who were insured with Medicare were less likely to receive standard-of-care postoperative radiotherapy and/or chemotherapy than those with private insurance (odds ratio: OR 0.80, . P . <. 0.001), as were those residing in the South (reference) in comparison to the Northeast, Atlantic, Great Lakes, and Midwest regions (OR 1.3-1.7, all . P . <. 0.001). Those residing in the Mountain region were even less likely to receive appropriate treatment (OR 0.7, . P . <. 0.001). Five-year stage IIIC/IV survival was 42.8% for non-Hispanic whites vs 24.6% for blacks (hazard ratio 1.3, . P . <. 0.001). Other factors associated with inferior 5-year survival included payer status (not insured, Medicaid, Medicare, vs private, ORs 1.2-1.3, all . P . <. 0.01), and treatment at low-volume centers (<. 5 vs ≥. 30. cases/year, HR 1.3, . P . <. 0.001). Conclusions and relevance: Socioeconomic, geographic and facility-related factors predict advanced endometrial cancer stage, failure to receive cancer care, and shorter survival. Black women had especially poor survival. Nationwide standardization and concentration of treatment at high-volume centers may improve outcomes.

Original languageEnglish (US)
JournalGynecologic Oncology
DOIs
StateAccepted/In press - Apr 29 2016

Fingerprint

Endometrial Neoplasms
Registries
Databases
Survival
Neoplasms
Medicare
Great Lakes Region
Therapeutics
Medicaid
Standard of Care
Insurance
Radiotherapy
Logistic Models
Odds Ratio
Drug Therapy

Keywords

  • Disparities
  • Endometrial cancer
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Disparities in treatment and survival for women with endometrial cancer : A contemporary national cancer database registry analysis. / Fader, Amanda N.; Habermann, Elizabeth B; Hanson, Kristine T.; Lin, Jeff F.; Grendys, Edward C.; Dowdy, Sean Christopher.

In: Gynecologic Oncology, 29.04.2016.

Research output: Contribution to journalArticle

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abstract = "Purpose: The study aim was to identify contemporary socioeconomic, racial, ethnic, and facility-related factors associated with stage at diagnosis, receipt of cancer treatment, and survival in women with endometrial cancer (EC). Patients and methods: Women diagnosed with EC between 1998 and 2010 were identified from the National Cancer Database. Variables associated with the outcomes of interest were assessed using multivariable Cox proportional hazards and logistic regression. Results: Among 228,511 women identified, the percentage of blacks with stage IIIC/IV disease at diagnosis was nearly twice that of non-Hispanic whites (17.8{\%} vs 9.8{\%}; . P . <. 0.001). Patients with advanced disease who were insured with Medicare were less likely to receive standard-of-care postoperative radiotherapy and/or chemotherapy than those with private insurance (odds ratio: OR 0.80, . P . <. 0.001), as were those residing in the South (reference) in comparison to the Northeast, Atlantic, Great Lakes, and Midwest regions (OR 1.3-1.7, all . P . <. 0.001). Those residing in the Mountain region were even less likely to receive appropriate treatment (OR 0.7, . P . <. 0.001). Five-year stage IIIC/IV survival was 42.8{\%} for non-Hispanic whites vs 24.6{\%} for blacks (hazard ratio 1.3, . P . <. 0.001). Other factors associated with inferior 5-year survival included payer status (not insured, Medicaid, Medicare, vs private, ORs 1.2-1.3, all . P . <. 0.01), and treatment at low-volume centers (<. 5 vs ≥. 30. cases/year, HR 1.3, . P . <. 0.001). Conclusions and relevance: Socioeconomic, geographic and facility-related factors predict advanced endometrial cancer stage, failure to receive cancer care, and shorter survival. Black women had especially poor survival. Nationwide standardization and concentration of treatment at high-volume centers may improve outcomes.",
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