Disease drivers of aging

Richard J. Hodes; Felipe Sierra; Steven N. Austad; Elissa Epel; Gretchen N. Neigh; Kristine M. Erlandson; Marissa J. Schafer; Nathan K. LeBrasseur; Christopher Wiley; Judith Campisi; Mary E. Sehl; Rosario Scalia; Satoru Eguchi; Balakuntalam S. Kasinath; Jeffrey B. Halter; Harvey Jay Cohen; Wendy Demark-Wahnefried; Tim A. Ahles; Nir Barzilai; Arti Hurria; Peter W. Hunt

doi:10.1111/nyas.13299

Disease drivers of aging

Richard J. Hodes, Felipe Sierra, Steven N. Austad, Elissa Epel, Gretchen N. Neigh, Kristine M. Erlandson, Marissa J. Schafer, Nathan K. LeBrasseur, Christopher Wiley, Judith Campisi, Mary E. Sehl, Rosario Scalia, Satoru Eguchi, Balakuntalam S. Kasinath, Jeffrey B. Halter, Harvey Jay Cohen, Wendy Demark-Wahnefried, Tim A. Ahles, Nir Barzilai, Arti HurriaPeter W. Hunt

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship—the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

Original language	English (US)
Pages (from-to)	45-68
Number of pages	24
Journal	Annals of the New York Academy of Sciences
Volume	1386
Issue number	1
DOIs	https://doi.org/10.1111/nyas.13299
State	Published - Dec 1 2016

Keywords

HIV
age-related
aging
cancer
chronic
diabetes
disease
pathology
prevention

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/nyas.13299

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Hodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., Sehl, M. E., Scalia, R., Eguchi, S., Kasinath, B. S., Halter, J. B., Cohen, H. J., Demark-Wahnefried, W., Ahles, T. A., Barzilai, N., ... Hunt, P. W. (2016). Disease drivers of aging. Annals of the New York Academy of Sciences, 1386(1), 45-68. https://doi.org/10.1111/nyas.13299

Hodes, RJ, Sierra, F, Austad, SN, Epel, E, Neigh, GN, Erlandson, KM, Schafer, MJ , LeBrasseur, NK, Wiley, C, Campisi, J, Sehl, ME, Scalia, R, Eguchi, S, Kasinath, BS, Halter, JB, Cohen, HJ, Demark-Wahnefried, W, Ahles, TA, Barzilai, N, Hurria, A & Hunt, PW 2016, 'Disease drivers of aging', Annals of the New York Academy of Sciences, vol. 1386, no. 1, pp. 45-68. https://doi.org/10.1111/nyas.13299

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abstract = "It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship—the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.",

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AU - Schafer, Marissa J.

AU - LeBrasseur, Nathan K.

AU - Wiley, Christopher

AU - Campisi, Judith

AU - Sehl, Mary E.

AU - Scalia, Rosario

AU - Eguchi, Satoru

AU - Kasinath, Balakuntalam S.

AU - Halter, Jeffrey B.

AU - Cohen, Harvey Jay

AU - Demark-Wahnefried, Wendy

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AU - Hurria, Arti

AU - Hunt, Peter W.

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AB - It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship—the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

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KW - chronic

KW - diabetes

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Disease drivers of aging

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