Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States

Chadi Nabhan, Michelle Byrtek, Ashish Rai, Keith Dawson, Xiaolei Zhou, Brian K. Link, Jonathan W. Friedberg, Andrew D. Zelenetz, Matthew J. Maurer, James R. Cerhan, Christopher R. Flowers

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Data from the National LymphoCare Study (a prospective, multicentre registry that enrolled follicular lymphoma (FL) patients from 2004 to 2007) were used to determine disease characteristics, treatment patterns, outcomes and prognosis for elderly FL (eFL) patients. Of 2650 FL patients, 209 (8%) were aged >80 years; these eFL patients more commonly had grade 3 disease, less frequently received chemoimmunotherapy and anthracyclines, and had lower response rates when compared to younger patients. With a median follow-up of 6.9 years, 5-year overall survival (OS) for eFL patients was 59%; 38% of deaths were lymphoma-related. No treatment produced superior OS among eFL patients. In multivariate Cox models, anaemia, B-symptoms and male sex predicted worse OS (P < 0·01); a prognostic index of these factors (0, 1 or ≥2 present) predicted OS [hazard ratio (95% CI): ≥2 vs. 0, 4·72 (2·38-9·33); 1 vs. 0, 2·63 (1·39-4·98)], with a higher concordance index (0·63) versus the Follicular Lymphoma International Prognostic Index (0·55). The index was validated in an independent cohort. In the largest prospective US-based eFL cohort, no optimal therapy was identified and nearly 40% of deaths were lymphoma-related, representing baseline outcomes in the modern era.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalBritish journal of haematology
Volume170
Issue number1
DOIs
StatePublished - Jul 1 2015

    Fingerprint

Keywords

  • Chemotherapy
  • Elderly lymphoma
  • Elderly patients
  • Follicular lymphoma
  • Rituximab

ASJC Scopus subject areas

  • Hematology

Cite this

Nabhan, C., Byrtek, M., Rai, A., Dawson, K., Zhou, X., Link, B. K., Friedberg, J. W., Zelenetz, A. D., Maurer, M. J., Cerhan, J. R., & Flowers, C. R. (2015). Disease characteristics, treatment patterns, prognosis, outcomes and lymphoma-related mortality in elderly follicular lymphoma in the United States. British journal of haematology, 170(1), 85-95. https://doi.org/10.1111/bjh.13399