Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

Edward L. Barnes; Laura Raffals; Millie D. Long; Gaurav Syal; Maia Kayal; Ashwin Ananthakrishnan; Benjamin Cohen; Joel Pekow; Parakkal Deepak; Jean Frederic Colombel; Hans H. Herfarth; Robert S. Sandler

doi:10.1093/crocol/otaa039

Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

Edward L. Barnes, Laura Raffals, Millie D. Long, Gaurav Syal, Maia Kayal, Ashwin Ananthakrishnan, Benjamin Cohen, Joel Pekow, Parakkal Deepak, Jean Frederic Colombel, Hans H. Herfarth, Robert S. Sandler

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system. Lay summary In a multicenter longitudinal cohort from 7 academic centers, a significant burden of inflammatory conditions of the pouch was demonstrated after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Crohn's and Colitis 360
Volume	2
Issue number	3
DOIs	https://doi.org/10.1093/crocol/otaa039
State	Published - Jul 1 2020

Keywords

Biologic therapy
Ileal pouch-anal anastomosis
Pouchitis

ASJC Scopus subject areas

Gastroenterology

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10.1093/crocol/otaa039

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Barnes, E. L., Raffals, L., Long, M. D., Syal, G., Kayal, M., Ananthakrishnan, A., Cohen, B., Pekow, J., Deepak, P., Colombel, J. F., Herfarth, H. H., & Sandler, R. S. (2020). Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States. Crohn's and Colitis 360, 2(3), 1-8. https://doi.org/10.1093/crocol/otaa039

Barnes, EL, Raffals, L, Long, MD, Syal, G, Kayal, M, Ananthakrishnan, A, Cohen, B, Pekow, J, Deepak, P, Colombel, JF, Herfarth, HH & Sandler, RS 2020, 'Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States', Crohn's and Colitis 360, vol. 2, no. 3, pp. 1-8. https://doi.org/10.1093/crocol/otaa039

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abstract = "Background: Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system. Lay summary In a multicenter longitudinal cohort from 7 academic centers, a significant burden of inflammatory conditions of the pouch was demonstrated after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.",

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author = "Barnes, {Edward L.} and Laura Raffals and Long, {Millie D.} and Gaurav Syal and Maia Kayal and Ashwin Ananthakrishnan and Benjamin Cohen and Joel Pekow and Parakkal Deepak and Colombel, {Jean Frederic} and Herfarth, {Hans H.} and Sandler, {Robert S.}",

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AU - Barnes, Edward L.

AU - Raffals, Laura

AU - Long, Millie D.

AU - Syal, Gaurav

AU - Kayal, Maia

AU - Ananthakrishnan, Ashwin

AU - Cohen, Benjamin

AU - Pekow, Joel

AU - Deepak, Parakkal

AU - Colombel, Jean Frederic

AU - Herfarth, Hans H.

AU - Sandler, Robert S.

PY - 2020/7/1

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N2 - Background: Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system. Lay summary In a multicenter longitudinal cohort from 7 academic centers, a significant burden of inflammatory conditions of the pouch was demonstrated after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.

AB - Background: Gaps exist in our understanding of the clinical course of pouch-related disorders. Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch. Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery. Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system. Lay summary In a multicenter longitudinal cohort from 7 academic centers, a significant burden of inflammatory conditions of the pouch was demonstrated after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.

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KW - Ileal pouch-anal anastomosis

KW - Pouchitis

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Disease and Treatment Patterns among Patients with Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States

Abstract

Keywords

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