Disease activity and mucosal healing in inflammatory bowel disease: a new role for histopathology?

Rish Pai, Karel Geboes

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Histologic evaluation of disease activity in the setting of inflammatory bowel disease is gaining interest within the gastroenterology community. Recent data suggests that histologic measurements of inflammation in ulcerative colitis are more sensitive at detecting disease activity and perform better than endoscopic measurements in predicting clinical outcomes. Histologic measurements are also increasingly used in ulcerative colitis clinical trials to assess response to new therapies. Histologic measurements of disease activity are less well studied in Crohn’s disease, but are gaining attention. Current published treatment algorithms in inflammatory bowel disease do not take into consideration histologic activity; however, this may change in the near future. In order for histologic measurements to be included in clinical decision-making, validated, reliable, and responsive histologic scoring systems are needed. In this review, the recent literature on the significance of histologic activity in both ulcerative colitis and Crohn’s disease is summarized. Histologic scoring systems are also briefly discussed.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalVirchows Archiv
Volume472
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Crohn's disease
  • Inflammatory bowel disease
  • Mucosal healing
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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