Discovery of new lesions in neurodegenerative diseases with monoclonal antibody techniques

Is there a non-amyloid precursor to senile plaques?

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The manuscript by Schmidt et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly labeled novel non- amyloid, plaque-like structures (AMY plaques) in aged and Alzheimer's disease brains. The full disclosure of the nature of these lesions awaits additional structural and biochemical studies, but at first glance there are interesting parallels between AMY plaques and recently described lesions composed of glia and glia-associated proteoglycans in brains of aged mice. The increasing recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans or their associated molecules attractive candidates for AMY-immunoreactive proteins. The relationship of AMY plaques to age-related glial changes that some have speculated may be precursors to senile plaques remains to be determined, as is the relationship of AMY plaques to more widely recognized amyloid-containing plaques. Future studies will determine whether AMY plaques are non-amyloid precursors to senile plaques or if they represent an independent type of structural lesion in the Alzheimer's disease brain. Ultimately, the clinical significance of AMY plaques will depend upon their characterization in brains of prospectively studied subjects.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalAmerican Journal of Pathology
Volume151
Issue number1
StatePublished - 1997
Externally publishedYes

Fingerprint

Amyloid Plaques
Neurodegenerative Diseases
Monoclonal Antibodies
Proteoglycans
Neuroglia
Brain
Alzheimer Disease
Manuscripts
Antibodies
Disclosure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{6f82c1c59a854f938f2120913a64f9e8,
title = "Discovery of new lesions in neurodegenerative diseases with monoclonal antibody techniques: Is there a non-amyloid precursor to senile plaques?",
abstract = "The manuscript by Schmidt et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly labeled novel non- amyloid, plaque-like structures (AMY plaques) in aged and Alzheimer's disease brains. The full disclosure of the nature of these lesions awaits additional structural and biochemical studies, but at first glance there are interesting parallels between AMY plaques and recently described lesions composed of glia and glia-associated proteoglycans in brains of aged mice. The increasing recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans or their associated molecules attractive candidates for AMY-immunoreactive proteins. The relationship of AMY plaques to age-related glial changes that some have speculated may be precursors to senile plaques remains to be determined, as is the relationship of AMY plaques to more widely recognized amyloid-containing plaques. Future studies will determine whether AMY plaques are non-amyloid precursors to senile plaques or if they represent an independent type of structural lesion in the Alzheimer's disease brain. Ultimately, the clinical significance of AMY plaques will depend upon their characterization in brains of prospectively studied subjects.",
author = "Dickson, {Dennis W}",
year = "1997",
language = "English (US)",
volume = "151",
pages = "7--11",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Discovery of new lesions in neurodegenerative diseases with monoclonal antibody techniques

T2 - Is there a non-amyloid precursor to senile plaques?

AU - Dickson, Dennis W

PY - 1997

Y1 - 1997

N2 - The manuscript by Schmidt et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly labeled novel non- amyloid, plaque-like structures (AMY plaques) in aged and Alzheimer's disease brains. The full disclosure of the nature of these lesions awaits additional structural and biochemical studies, but at first glance there are interesting parallels between AMY plaques and recently described lesions composed of glia and glia-associated proteoglycans in brains of aged mice. The increasing recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans or their associated molecules attractive candidates for AMY-immunoreactive proteins. The relationship of AMY plaques to age-related glial changes that some have speculated may be precursors to senile plaques remains to be determined, as is the relationship of AMY plaques to more widely recognized amyloid-containing plaques. Future studies will determine whether AMY plaques are non-amyloid precursors to senile plaques or if they represent an independent type of structural lesion in the Alzheimer's disease brain. Ultimately, the clinical significance of AMY plaques will depend upon their characterization in brains of prospectively studied subjects.

AB - The manuscript by Schmidt et al reports that antibodies generated to paired helical filaments (AMY antibodies) unexpectedly labeled novel non- amyloid, plaque-like structures (AMY plaques) in aged and Alzheimer's disease brains. The full disclosure of the nature of these lesions awaits additional structural and biochemical studies, but at first glance there are interesting parallels between AMY plaques and recently described lesions composed of glia and glia-associated proteoglycans in brains of aged mice. The increasing recognition of the role of proteoglycans in paired helical filaments formation makes proteoglycans or their associated molecules attractive candidates for AMY-immunoreactive proteins. The relationship of AMY plaques to age-related glial changes that some have speculated may be precursors to senile plaques remains to be determined, as is the relationship of AMY plaques to more widely recognized amyloid-containing plaques. Future studies will determine whether AMY plaques are non-amyloid precursors to senile plaques or if they represent an independent type of structural lesion in the Alzheimer's disease brain. Ultimately, the clinical significance of AMY plaques will depend upon their characterization in brains of prospectively studied subjects.

UR - http://www.scopus.com/inward/record.url?scp=0030847074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030847074&partnerID=8YFLogxK

M3 - Article

VL - 151

SP - 7

EP - 11

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 1

ER -