Discovery, development, and future application of senolytics: theories and predictions

Erin O. Wissler Gerdes, Yi Zhu, Tamar Tchkonia, James L. Kirkland

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health costs. Senescent cells do not replicate, can release factors that cause tissue dysfunction, and yet remain viable. The discovery of senolytic drugs, agents that selectively eliminate senescent cells, created a new route for alleviating age-related dysfunction and diseases. As anticipated for agents targeting fundamental aging mechanisms that are ‘root cause’ contributors to multiple disorders, potential applications of senolytics are protean. We review the discovery of senolytics, strategies for translation into clinical application, and promising early signals from clinical trials.

Original languageEnglish (US)
Pages (from-to)2418-2427
Number of pages10
JournalFEBS Journal
Volume287
Issue number12
DOIs
StatePublished - Jun 1 2020

Keywords

  • Geroscience Hypothesis
  • MAD cells
  • SASP
  • SCAPs
  • dasatinib
  • fisetin
  • navitoclax
  • quercetin
  • senolytics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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