Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Brianna B. Williams, Andrew H. Van Benschoten, Peter Cimermancic, Mohamed S. Donia, Michael Zimmermann, Mao Taketani, Atsushi Ishihara, Purna C Kashyap, James S. Fraser, Michael A. Fischbach

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Gut microbiota produce tryptamine via tryptophan (Trp) decarboxylationTwo bacterial Trp decarboxylases from gut Firmicutes were identified and characterizedStructure of one of the tryptophan decarboxylase suggests catalytic mechanism>10% of healthy humans harbor a Trp decarboxylase in their gut microbiome

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalCell Host and Microbe
Volume16
Issue number4
DOIs
StatePublished - Oct 8 2014

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Aromatic-L-Amino-Acid Decarboxylases
Carboxy-Lyases
Neurotransmitter Agents
Tryptophan
Gastrointestinal Microbiome
tryptamine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., ... Fischbach, M. A. (2014). Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host and Microbe, 16(4), 495-503. https://doi.org/10.1016/j.chom.2014.09.001

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. / Williams, Brianna B.; Van Benschoten, Andrew H.; Cimermancic, Peter; Donia, Mohamed S.; Zimmermann, Michael; Taketani, Mao; Ishihara, Atsushi; Kashyap, Purna C; Fraser, James S.; Fischbach, Michael A.

In: Cell Host and Microbe, Vol. 16, No. 4, 08.10.2014, p. 495-503.

Research output: Contribution to journalArticle

Williams, BB, Van Benschoten, AH, Cimermancic, P, Donia, MS, Zimmermann, M, Taketani, M, Ishihara, A, Kashyap, PC, Fraser, JS & Fischbach, MA 2014, 'Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine', Cell Host and Microbe, vol. 16, no. 4, pp. 495-503. https://doi.org/10.1016/j.chom.2014.09.001
Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host and Microbe. 2014 Oct 8;16(4):495-503. https://doi.org/10.1016/j.chom.2014.09.001
Williams, Brianna B. ; Van Benschoten, Andrew H. ; Cimermancic, Peter ; Donia, Mohamed S. ; Zimmermann, Michael ; Taketani, Mao ; Ishihara, Atsushi ; Kashyap, Purna C ; Fraser, James S. ; Fischbach, Michael A. / Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. In: Cell Host and Microbe. 2014 ; Vol. 16, No. 4. pp. 495-503.
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