TY - JOUR
T1 - Disconnected pancreatic duct syndrome in severe acute pancreatitis
T2 - clinical and imaging characteristics and outcomes in a cohort of 31 cases
AU - Pelaez-Luna, Mario
AU - Vege, Santhi Swaroop
AU - Petersen, Bret T.
AU - Chari, Suresh T.
AU - Clain, Jonathan E.
AU - Levy, Michael J.
AU - Pearson, Randal K.
AU - Topazian, Mark D.
AU - Farnell, Michael B.
AU - Kendrick, Michael L.
AU - Baron, Todd H.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/7
Y1 - 2008/7
N2 - Background: Information regarding the natural history, clinical characteristics, and outcomes of disconnected pancreatic duct syndrome (DPDS) is limited. Objective: To describe clinical characteristics and outcomes of DPDS. Design: A retrospective review of the Mayo Clinic endoscopy and hospital service database. Setting: Tertiary-referral center. Patients: We identified 31 DPDS cases from 1999 to 2006. Interventions: Endoscopic drainage of pancreatic-fluid collections. Main Outcome Measurements: The relationship between demographic and clinical data with endoscopic treatment and clinical outcomes in DPDS cases. Results: The median patient age was 53 years (range 20-83 years); 48% were men. The most common etiology of acute pancreatitis (AP) was biliary (55%) followed by idiopathic (27%). The median interval between the diagnoses of AP and DPDS was 56 days (range 3-251 days); the median follow-up after the last ERCP or surgical procedure was 7 months (range 0-90 months). The DPDS location included the following: pancreas head 6%, neck 58%, body 26%, and tail 10%. Twenty-six patients had initial endoscopic treatment (19 had long-term improvement; 7 failed treatment and required surgery) and 5 underwent immediate surgery. Mortality was 0%; 26% developed chronic pancreatitis (CP) and 16% diabetes mellitus (DM); 10% resolved completely, 45% had smaller fluid collections, and 26% patients were lost to follow-up. No relationship between demographic and clinical data with endoscopic and clinical outcomes was found. Conclusions: Endoscopic treatment temporarily improved DPDS, with a failure rate of 23%. Immediate surgery was not required in all cases. CP and/or pancreatic atrophy occurred relatively shortly after the DPDS diagnosis in 26% and DM in 16% of cases. DPDS did not lead to mortality. Early surgery may be considered after initially stabilizing the fluid collection with endoscopic therapy.
AB - Background: Information regarding the natural history, clinical characteristics, and outcomes of disconnected pancreatic duct syndrome (DPDS) is limited. Objective: To describe clinical characteristics and outcomes of DPDS. Design: A retrospective review of the Mayo Clinic endoscopy and hospital service database. Setting: Tertiary-referral center. Patients: We identified 31 DPDS cases from 1999 to 2006. Interventions: Endoscopic drainage of pancreatic-fluid collections. Main Outcome Measurements: The relationship between demographic and clinical data with endoscopic treatment and clinical outcomes in DPDS cases. Results: The median patient age was 53 years (range 20-83 years); 48% were men. The most common etiology of acute pancreatitis (AP) was biliary (55%) followed by idiopathic (27%). The median interval between the diagnoses of AP and DPDS was 56 days (range 3-251 days); the median follow-up after the last ERCP or surgical procedure was 7 months (range 0-90 months). The DPDS location included the following: pancreas head 6%, neck 58%, body 26%, and tail 10%. Twenty-six patients had initial endoscopic treatment (19 had long-term improvement; 7 failed treatment and required surgery) and 5 underwent immediate surgery. Mortality was 0%; 26% developed chronic pancreatitis (CP) and 16% diabetes mellitus (DM); 10% resolved completely, 45% had smaller fluid collections, and 26% patients were lost to follow-up. No relationship between demographic and clinical data with endoscopic and clinical outcomes was found. Conclusions: Endoscopic treatment temporarily improved DPDS, with a failure rate of 23%. Immediate surgery was not required in all cases. CP and/or pancreatic atrophy occurred relatively shortly after the DPDS diagnosis in 26% and DM in 16% of cases. DPDS did not lead to mortality. Early surgery may be considered after initially stabilizing the fluid collection with endoscopic therapy.
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U2 - 10.1016/j.gie.2007.11.041
DO - 10.1016/j.gie.2007.11.041
M3 - Article
C2 - 18378234
AN - SCOPUS:45449119100
SN - 0016-5107
VL - 68
SP - 91
EP - 97
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 1
ER -