Directional posterior corneal profile changes in fuchs’ endothelial corneal dystrophy

Katrin Wacker, Jay W. McLaren, Sanjay V. Patel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

PURPOSE. To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs’ endothelial corneal dystrophy (FECD).METHODS. Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema. Normal corneas were devoid of guttae. Peripheral thickness centered on the corneal apex, and radii of posterior curvature were measured with Scheimpflug imaging. Variables were compared between groups by using generalized estimating equation models. RESULTS. Scheimpflug images were acquired in 101 normal corneas and 112 corneas with FECD. Normal corneas were 8.6 6 4.8 lm thicker vertically than horizontally (P = 0.001); the steep posterior meridian was vertical in 91% of corneas. The difference between vertical and horizontal thicknesses decreased to 4.7 ± 7.3 μm in advanced FECD (P = 0.008); 46% had a steep vertical posterior meridian (P = 0.001). Vertical radius of curvature was flatter than normal in moderate (by 0.2 mm, P = 0.011) and advanced (by 0.4 mm, P < 0.001) FECD. Mean posterior corneal power was less negative in moderate (by 0.2 diopters [D], P = 0.009) and advanced (by 0.4 D, P < 0.001) FECD compared to normal. CONCLUSIONS. Posterior toricity is abnormal in advanced FECD because of relatively greater horizontal than vertical corneal thickening. Posterior corneal power decreases (i.e., is less negative) in moderate and advanced FECD, which can affect the choice of intraocular lens power during cataract surgery, and might explain the hyperopic shift after Descemet membrane endothelial keratoplasty.

Original languageEnglish (US)
Pages (from-to)5904-5911
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number10
DOIs
StatePublished - 2015

Fingerprint

Fuchs' Endothelial Dystrophy
Cornea
Meridians
Descemet Membrane
Corneal Transplantation
Astigmatism
Intraocular Lenses
Cataract
Edema

Keywords

  • Astigmatism
  • Corneal power
  • Corneal thickness
  • Fuchs’ endothelial corneal dystrophy
  • Posterior cornea
  • Scheimpflug imaging

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Directional posterior corneal profile changes in fuchs’ endothelial corneal dystrophy. / Wacker, Katrin; McLaren, Jay W.; Patel, Sanjay V.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 10, 2015, p. 5904-5911.

Research output: Contribution to journalArticle

Wacker, Katrin ; McLaren, Jay W. ; Patel, Sanjay V. / Directional posterior corneal profile changes in fuchs’ endothelial corneal dystrophy. In: Investigative Ophthalmology and Visual Science. 2015 ; Vol. 56, No. 10. pp. 5904-5911.
@article{bddcce30f8444545b8f69cc10b4aa3d5,
title = "Directional posterior corneal profile changes in fuchs’ endothelial corneal dystrophy",
abstract = "PURPOSE. To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs’ endothelial corneal dystrophy (FECD).METHODS. Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema. Normal corneas were devoid of guttae. Peripheral thickness centered on the corneal apex, and radii of posterior curvature were measured with Scheimpflug imaging. Variables were compared between groups by using generalized estimating equation models. RESULTS. Scheimpflug images were acquired in 101 normal corneas and 112 corneas with FECD. Normal corneas were 8.6 6 4.8 lm thicker vertically than horizontally (P = 0.001); the steep posterior meridian was vertical in 91{\%} of corneas. The difference between vertical and horizontal thicknesses decreased to 4.7 ± 7.3 μm in advanced FECD (P = 0.008); 46{\%} had a steep vertical posterior meridian (P = 0.001). Vertical radius of curvature was flatter than normal in moderate (by 0.2 mm, P = 0.011) and advanced (by 0.4 mm, P < 0.001) FECD. Mean posterior corneal power was less negative in moderate (by 0.2 diopters [D], P = 0.009) and advanced (by 0.4 D, P < 0.001) FECD compared to normal. CONCLUSIONS. Posterior toricity is abnormal in advanced FECD because of relatively greater horizontal than vertical corneal thickening. Posterior corneal power decreases (i.e., is less negative) in moderate and advanced FECD, which can affect the choice of intraocular lens power during cataract surgery, and might explain the hyperopic shift after Descemet membrane endothelial keratoplasty.",
keywords = "Astigmatism, Corneal power, Corneal thickness, Fuchs’ endothelial corneal dystrophy, Posterior cornea, Scheimpflug imaging",
author = "Katrin Wacker and McLaren, {Jay W.} and Patel, {Sanjay V.}",
year = "2015",
doi = "10.1167/iovs.15-17311",
language = "English (US)",
volume = "56",
pages = "5904--5911",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "10",

}

TY - JOUR

T1 - Directional posterior corneal profile changes in fuchs’ endothelial corneal dystrophy

AU - Wacker, Katrin

AU - McLaren, Jay W.

AU - Patel, Sanjay V.

PY - 2015

Y1 - 2015

N2 - PURPOSE. To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs’ endothelial corneal dystrophy (FECD).METHODS. Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema. Normal corneas were devoid of guttae. Peripheral thickness centered on the corneal apex, and radii of posterior curvature were measured with Scheimpflug imaging. Variables were compared between groups by using generalized estimating equation models. RESULTS. Scheimpflug images were acquired in 101 normal corneas and 112 corneas with FECD. Normal corneas were 8.6 6 4.8 lm thicker vertically than horizontally (P = 0.001); the steep posterior meridian was vertical in 91% of corneas. The difference between vertical and horizontal thicknesses decreased to 4.7 ± 7.3 μm in advanced FECD (P = 0.008); 46% had a steep vertical posterior meridian (P = 0.001). Vertical radius of curvature was flatter than normal in moderate (by 0.2 mm, P = 0.011) and advanced (by 0.4 mm, P < 0.001) FECD. Mean posterior corneal power was less negative in moderate (by 0.2 diopters [D], P = 0.009) and advanced (by 0.4 D, P < 0.001) FECD compared to normal. CONCLUSIONS. Posterior toricity is abnormal in advanced FECD because of relatively greater horizontal than vertical corneal thickening. Posterior corneal power decreases (i.e., is less negative) in moderate and advanced FECD, which can affect the choice of intraocular lens power during cataract surgery, and might explain the hyperopic shift after Descemet membrane endothelial keratoplasty.

AB - PURPOSE. To determine directional changes in peripheral corneal thickness and corneal astigmatism over a range of severity of Fuchs’ endothelial corneal dystrophy (FECD).METHODS. Eyes with FECD were categorized as mild, moderate, or advanced according to the area and confluence of guttae and the presence of clinical edema. Normal corneas were devoid of guttae. Peripheral thickness centered on the corneal apex, and radii of posterior curvature were measured with Scheimpflug imaging. Variables were compared between groups by using generalized estimating equation models. RESULTS. Scheimpflug images were acquired in 101 normal corneas and 112 corneas with FECD. Normal corneas were 8.6 6 4.8 lm thicker vertically than horizontally (P = 0.001); the steep posterior meridian was vertical in 91% of corneas. The difference between vertical and horizontal thicknesses decreased to 4.7 ± 7.3 μm in advanced FECD (P = 0.008); 46% had a steep vertical posterior meridian (P = 0.001). Vertical radius of curvature was flatter than normal in moderate (by 0.2 mm, P = 0.011) and advanced (by 0.4 mm, P < 0.001) FECD. Mean posterior corneal power was less negative in moderate (by 0.2 diopters [D], P = 0.009) and advanced (by 0.4 D, P < 0.001) FECD compared to normal. CONCLUSIONS. Posterior toricity is abnormal in advanced FECD because of relatively greater horizontal than vertical corneal thickening. Posterior corneal power decreases (i.e., is less negative) in moderate and advanced FECD, which can affect the choice of intraocular lens power during cataract surgery, and might explain the hyperopic shift after Descemet membrane endothelial keratoplasty.

KW - Astigmatism

KW - Corneal power

KW - Corneal thickness

KW - Fuchs’ endothelial corneal dystrophy

KW - Posterior cornea

KW - Scheimpflug imaging

UR - http://www.scopus.com/inward/record.url?scp=84941365957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941365957&partnerID=8YFLogxK

U2 - 10.1167/iovs.15-17311

DO - 10.1167/iovs.15-17311

M3 - Article

C2 - 26348640

AN - SCOPUS:84941365957

VL - 56

SP - 5904

EP - 5911

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 10

ER -