Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging

Zang Hee Cho, Se Hong Oh, Jong Min Kim, Sung Yeon Park, Dae Hyuk Kwon, Hye Jin Jeong, Young Bo Kim, Je Geun Chi, Chan Woong Park, John III Huston, Kendall H Lee, Beom S. Jeon

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age-matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean "arch" shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch-like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age-dependent correlation and substantially stronger UPDRS motor score-dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD.

Original languageEnglish (US)
Pages (from-to)713-718
Number of pages6
JournalMovement Disorders
Volume26
Issue number4
DOIs
StatePublished - Mar 2011

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Neuroimaging
Parkinson Disease
Substantia Nigra
Magnetic Resonance Imaging
Dopaminergic Neurons
Neurodegenerative Diseases

Keywords

  • 7.0T MRI
  • Brain imaging
  • Neurodegenerative disorder
  • Parkinson's disease
  • Substantia nigra

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Cho, Z. H., Oh, S. H., Kim, J. M., Park, S. Y., Kwon, D. H., Jeong, H. J., ... Jeon, B. S. (2011). Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. Movement Disorders, 26(4), 713-718. https://doi.org/10.1002/mds.23465

Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. / Cho, Zang Hee; Oh, Se Hong; Kim, Jong Min; Park, Sung Yeon; Kwon, Dae Hyuk; Jeong, Hye Jin; Kim, Young Bo; Chi, Je Geun; Park, Chan Woong; Huston, John III; Lee, Kendall H; Jeon, Beom S.

In: Movement Disorders, Vol. 26, No. 4, 03.2011, p. 713-718.

Research output: Contribution to journalArticle

Cho, ZH, Oh, SH, Kim, JM, Park, SY, Kwon, DH, Jeong, HJ, Kim, YB, Chi, JG, Park, CW, Huston, JIII, Lee, KH & Jeon, BS 2011, 'Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging', Movement Disorders, vol. 26, no. 4, pp. 713-718. https://doi.org/10.1002/mds.23465
Cho, Zang Hee ; Oh, Se Hong ; Kim, Jong Min ; Park, Sung Yeon ; Kwon, Dae Hyuk ; Jeong, Hye Jin ; Kim, Young Bo ; Chi, Je Geun ; Park, Chan Woong ; Huston, John III ; Lee, Kendall H ; Jeon, Beom S. / Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. In: Movement Disorders. 2011 ; Vol. 26, No. 4. pp. 713-718.
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