Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: A population-based longitudinal study

Kevin P. Cohoon, Cynthia L. Leibson, Jeanine E. Ransom, Aneel Arjun Ashrani, Myung (Michelle) S Park, Tanya M. Petterson, Kirsten Hall Long, Kent R Bailey, John A. Heit

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Abstract

Background We estimated medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for major operation. Methods Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN, residents with objectively diagnosed incident VTE within 92 days of hospitalization for major operation during an 18-year period, 1988-2005 (n = 355). One Olmsted County resident hospitalized for major operation without VTE was matched to each case on event date (±1 year), type of operation, duration of previous medical history, and active cancer status. Subjects were followed in Rochester Epidemiology Project provider-linked billing data for standardized, inflation-adjusted direct medical costs from 1 year before index (case's VTE event date and control's matched date) to earliest of death, emigration, or December 31, 2011. We used generalized linear modeling to predict costs for cases and controls and used bootstrapping methods to assess uncertainty and significance of mean adjusted cost differences. Results Adjusted mean predicted costs were more than 1.5-fold greater for cases ($55,956) than for controls ($32,718) (P ≤.001) from index to up to 5 years postindex. Cost differences between cases and controls were greatest within the first 3 months after index (mean difference = $12,381). Costs were greater for cases than controls (mean difference = $10,797) from 3 months to up to 5 years postindex and together accounted for about half of the overall cost difference. Conclusion VTE during or after recent hospitalization for major operation contributes a substantial economic burden; VTE-attributable costs are greatest in the initial 3 months but persist for up to 5 years.

Original languageEnglish (US)
Pages (from-to)423-431
Number of pages9
JournalSurgery (United States)
Volume157
Issue number3
DOIs
StatePublished - Mar 1 2015

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Venous Thromboembolism
Longitudinal Studies
Costs and Cost Analysis
Population
Epidemiology
Hospitalization
Cost Control
Emigration and Immigration
Economic Inflation
Uncertainty
Economics

ASJC Scopus subject areas

  • Surgery

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Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation : A population-based longitudinal study. / Cohoon, Kevin P.; Leibson, Cynthia L.; Ransom, Jeanine E.; Ashrani, Aneel Arjun; Park, Myung (Michelle) S; Petterson, Tanya M.; Long, Kirsten Hall; Bailey, Kent R; Heit, John A.

In: Surgery (United States), Vol. 157, No. 3, 01.03.2015, p. 423-431.

Research output: Contribution to journalArticle

Cohoon, Kevin P. ; Leibson, Cynthia L. ; Ransom, Jeanine E. ; Ashrani, Aneel Arjun ; Park, Myung (Michelle) S ; Petterson, Tanya M. ; Long, Kirsten Hall ; Bailey, Kent R ; Heit, John A. / Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation : A population-based longitudinal study. In: Surgery (United States). 2015 ; Vol. 157, No. 3. pp. 423-431.
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abstract = "Background We estimated medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for major operation. Methods Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN, residents with objectively diagnosed incident VTE within 92 days of hospitalization for major operation during an 18-year period, 1988-2005 (n = 355). One Olmsted County resident hospitalized for major operation without VTE was matched to each case on event date (±1 year), type of operation, duration of previous medical history, and active cancer status. Subjects were followed in Rochester Epidemiology Project provider-linked billing data for standardized, inflation-adjusted direct medical costs from 1 year before index (case's VTE event date and control's matched date) to earliest of death, emigration, or December 31, 2011. We used generalized linear modeling to predict costs for cases and controls and used bootstrapping methods to assess uncertainty and significance of mean adjusted cost differences. Results Adjusted mean predicted costs were more than 1.5-fold greater for cases ($55,956) than for controls ($32,718) (P ≤.001) from index to up to 5 years postindex. Cost differences between cases and controls were greatest within the first 3 months after index (mean difference = $12,381). Costs were greater for cases than controls (mean difference = $10,797) from 3 months to up to 5 years postindex and together accounted for about half of the overall cost difference. Conclusion VTE during or after recent hospitalization for major operation contributes a substantial economic burden; VTE-attributable costs are greatest in the initial 3 months but persist for up to 5 years.",
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T2 - A population-based longitudinal study

AU - Cohoon, Kevin P.

AU - Leibson, Cynthia L.

AU - Ransom, Jeanine E.

AU - Ashrani, Aneel Arjun

AU - Park, Myung (Michelle) S

AU - Petterson, Tanya M.

AU - Long, Kirsten Hall

AU - Bailey, Kent R

AU - Heit, John A.

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N2 - Background We estimated medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for major operation. Methods Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN, residents with objectively diagnosed incident VTE within 92 days of hospitalization for major operation during an 18-year period, 1988-2005 (n = 355). One Olmsted County resident hospitalized for major operation without VTE was matched to each case on event date (±1 year), type of operation, duration of previous medical history, and active cancer status. Subjects were followed in Rochester Epidemiology Project provider-linked billing data for standardized, inflation-adjusted direct medical costs from 1 year before index (case's VTE event date and control's matched date) to earliest of death, emigration, or December 31, 2011. We used generalized linear modeling to predict costs for cases and controls and used bootstrapping methods to assess uncertainty and significance of mean adjusted cost differences. Results Adjusted mean predicted costs were more than 1.5-fold greater for cases ($55,956) than for controls ($32,718) (P ≤.001) from index to up to 5 years postindex. Cost differences between cases and controls were greatest within the first 3 months after index (mean difference = $12,381). Costs were greater for cases than controls (mean difference = $10,797) from 3 months to up to 5 years postindex and together accounted for about half of the overall cost difference. Conclusion VTE during or after recent hospitalization for major operation contributes a substantial economic burden; VTE-attributable costs are greatest in the initial 3 months but persist for up to 5 years.

AB - Background We estimated medical costs attributable to venous thromboembolism (VTE) among patients currently or recently hospitalized for major operation. Methods Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN, residents with objectively diagnosed incident VTE within 92 days of hospitalization for major operation during an 18-year period, 1988-2005 (n = 355). One Olmsted County resident hospitalized for major operation without VTE was matched to each case on event date (±1 year), type of operation, duration of previous medical history, and active cancer status. Subjects were followed in Rochester Epidemiology Project provider-linked billing data for standardized, inflation-adjusted direct medical costs from 1 year before index (case's VTE event date and control's matched date) to earliest of death, emigration, or December 31, 2011. We used generalized linear modeling to predict costs for cases and controls and used bootstrapping methods to assess uncertainty and significance of mean adjusted cost differences. Results Adjusted mean predicted costs were more than 1.5-fold greater for cases ($55,956) than for controls ($32,718) (P ≤.001) from index to up to 5 years postindex. Cost differences between cases and controls were greatest within the first 3 months after index (mean difference = $12,381). Costs were greater for cases than controls (mean difference = $10,797) from 3 months to up to 5 years postindex and together accounted for about half of the overall cost difference. Conclusion VTE during or after recent hospitalization for major operation contributes a substantial economic burden; VTE-attributable costs are greatest in the initial 3 months but persist for up to 5 years.

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