Direct gene delivery strategies for the treatment of rheumatoid arthritis

Steven C. Ghivizzani, Thomas J. Oligino, Joseph C. Glorioso, Paul D. Robbins, Christopher H Evans

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalDrug Discovery Today
Volume6
Issue number5
DOIs
StatePublished - Mar 1 2001
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Joints
Genes
Transgenes
Therapeutics
Dependovirus
Animal Diseases
Experimental Arthritis
Simplexvirus
Retroviridae
Adenoviridae
Genetic Therapy
Arthritis
Disease Progression
Complementary DNA
Gene Expression
Injections
Proteins

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Direct gene delivery strategies for the treatment of rheumatoid arthritis. / Ghivizzani, Steven C.; Oligino, Thomas J.; Glorioso, Joseph C.; Robbins, Paul D.; Evans, Christopher H.

In: Drug Discovery Today, Vol. 6, No. 5, 01.03.2001, p. 259-267.

Research output: Contribution to journalArticle

Ghivizzani, Steven C. ; Oligino, Thomas J. ; Glorioso, Joseph C. ; Robbins, Paul D. ; Evans, Christopher H. / Direct gene delivery strategies for the treatment of rheumatoid arthritis. In: Drug Discovery Today. 2001 ; Vol. 6, No. 5. pp. 259-267.
@article{e5cfbf32f4f84712934084b9626dafb7,
title = "Direct gene delivery strategies for the treatment of rheumatoid arthritis",
abstract = "Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.",
author = "Ghivizzani, {Steven C.} and Oligino, {Thomas J.} and Glorioso, {Joseph C.} and Robbins, {Paul D.} and Evans, {Christopher H}",
year = "2001",
month = "3",
day = "1",
doi = "10.1016/S1359-6446(01)01685-3",
language = "English (US)",
volume = "6",
pages = "259--267",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Direct gene delivery strategies for the treatment of rheumatoid arthritis

AU - Ghivizzani, Steven C.

AU - Oligino, Thomas J.

AU - Glorioso, Joseph C.

AU - Robbins, Paul D.

AU - Evans, Christopher H

PY - 2001/3/1

Y1 - 2001/3/1

N2 - Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.

AB - Gene therapy offers a novel and innovative approach to the delivery of therapeutic proteins to the joints of patients with arthritis. Several viral vectors, including adenovirus, adeno-associated virus, retrovirus and herpes simplex virus, are capable of delivering exogenous cDNAs to the synovial lining, enabling effective levels of intra-articular transgene expression following direct injection to the joint. The expression of certain gene products has proven to be sufficient to inhibit the progression of disease in animals with experimental arthritis. Non-viral methods of gene transfer, however, are less satisfactory, and are limited by toxicity and transience of expression. Although the principle of direct gene delivery to the joint has been demonstrated, maintaining persistent intra-articular transgene expression remains a challenge.

UR - http://www.scopus.com/inward/record.url?scp=0001762706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001762706&partnerID=8YFLogxK

U2 - 10.1016/S1359-6446(01)01685-3

DO - 10.1016/S1359-6446(01)01685-3

M3 - Article

AN - SCOPUS:0001762706

VL - 6

SP - 259

EP - 267

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 5

ER -