Direct and neurally mediated effects of halothane on pulmonary resistance in vivo

David Oman Warner, J. Vettermann, J. F. Brichant, K. Rehder

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

It has been suggested that halothane inhibits contraction of airway smooth muscle in vivo mainly by reducing reflex activity in nerves innervating the muscle with only minimal direct effects on the muscle itself. To examine possible mechanisms of action of halothane at clinically relevant concentrations the authors studied the effect of halothane on increases in pulmonary resistance (R(L)) produced by either vagus nerve stimulation (VNS, which caused neurally mediated constriction) or the inhalation of nebulized acetylcholine (ACh, which directly stimulated the smooth muscle cell) in nine mongrel dogs. The frequency of bilateral VNS and the dose of nebulized ACh were adjusted to produce approximately equal increases in R(L). Halothane reduced the response to both types of stimulation in a dose-dependent fashion. At halothane concentrations greater than or equal to 0.4 MAC, the VNS response was significantly less than the ACh response. When tetrodotoxin was given to block neural activity, the ACh response was unchanged, confirming that neural activation did not contribute significantly to smooth muscle contraction in response to ACh. The authors conclude that in addition to neurally mediated effects, halothane at clinically used concentrations has significant direct effects on airway smooth muscle stimulated by ACh. The relative importance of each factor in vivo should depend on the stimulus that caused contraction of airway smooth muscle.

Original languageEnglish (US)
Pages (from-to)1057-1063
Number of pages7
JournalAnesthesiology
Volume72
Issue number6
StatePublished - 1990

Fingerprint

Halothane
Lung
Smooth Muscle
Vagus Nerve Stimulation
Muscles
Tetrodotoxin
Muscle Contraction
Constriction
Inhalation
Acetylcholine
Smooth Muscle Myocytes
Reflex
Dogs

Keywords

  • anesthetics, volatile: halothane
  • lungs: airway resistance; dynamic compliance; pulmonary resistance
  • muscle, smooth: airway
  • nerve, vagus: stimulation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Warner, D. O., Vettermann, J., Brichant, J. F., & Rehder, K. (1990). Direct and neurally mediated effects of halothane on pulmonary resistance in vivo. Anesthesiology, 72(6), 1057-1063.

Direct and neurally mediated effects of halothane on pulmonary resistance in vivo. / Warner, David Oman; Vettermann, J.; Brichant, J. F.; Rehder, K.

In: Anesthesiology, Vol. 72, No. 6, 1990, p. 1057-1063.

Research output: Contribution to journalArticle

Warner, DO, Vettermann, J, Brichant, JF & Rehder, K 1990, 'Direct and neurally mediated effects of halothane on pulmonary resistance in vivo', Anesthesiology, vol. 72, no. 6, pp. 1057-1063.
Warner, David Oman ; Vettermann, J. ; Brichant, J. F. ; Rehder, K. / Direct and neurally mediated effects of halothane on pulmonary resistance in vivo. In: Anesthesiology. 1990 ; Vol. 72, No. 6. pp. 1057-1063.
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