Dipyridamole vasodilator response after human orthotopic heart transplantation

Quantification by oxygen-15-labeled water and positron emission tomography

Eldad Rechavia, Luis I. Araujo, Ranil de Silva, Sudhir S. Kushwaha, Adriaan A. Lammertsma, Terry Jones, Andrew Mitchell, A'ttilio Maseri, Magdi H. Yacoub

Research output: Contribution to journalArticle

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Abstract

To assess coronary vasodilator restore after orthotopic heart transplantation, regional myocardial perfusion was measured with oxygen-15-labeled water and dynamic positron emission tomography in 14 cardiac allograft recipients who were not experiencing rejection and who had no angiographic evidence of epicardial coronary sclerosis 15 to 73 months (mean ± SD 43 ± 19) after transplantation (group I). Twelve normal men with an average age of 31 years (group II) served as a control group. Regional perfusion was measured at rest and after the intravenous administration of 0.6 mg/kg body weight of dipyridamole. Rest regional myocardial blood flow was homogeneously distributed throughout the left ventricle and was significantly higher in transplant recipients (mean 1.16 ± 0.26 ml/g per min [range 0.8 to 1.73] than in normal subjects mean 0.85 ± 0.13 ml/g per min [range 0.57 to 0.99); p = 0.001) as was rest heart rate-systoll blood pressure product (rate-pressure product 11,255 ± 2,540 vs. 7,073 ± 1,306; p < 0.001). After dipyridamole, perfusion in the transplant recipients was homogeneous and slightly lower (2.73 ±1.03 vs. 3.40 ± 1.09 ml/g per min; p = NS), whereas rate-pressure product was slightly higher (12,179 ± 2,266 vs. 10,885 ± 1,895: p = NS) than the value in normal subjects. Dipyridamole vasodilator response (dipyridamole/rest myocardial blood flow) ranged from 1.23 to 4.92 (mean 2.50 ± 1.13) in group I and from 2.65 to 5.45 (3.97 ± 0.89) in group II (p = 0.001). Rate-pressure product change (dipyridammole/rest rate-pressure product) was markedly attenuated in transplant recipients compred with the value in normal subjects (1.09 ± 0.09 vs. 1.56 ± 0.27 ml/g/per min; p < 0,001). Normalization for the difference in rest rate-pressure product for each individual subject showed that the adjusted rest show values (group 11.19 ± 0.27, group II 1.39 ± 0.31 ml/g per min; p = NS) and the dipyridamole-vasodilator response data (group I 2.45 ± 0.64, group II 2.47 ± 1.23, p = NS) in the two groups were not significantly different. Thus, in transplant recipients who are not experiencing rejection, the respons iveness of the coronary vasculature to dipyridamole-mediated vasodilation is uniformly preserved among all regions of the left ventricular myocardium.

Original languageEnglish (US)
Pages (from-to)100-106
Number of pages7
JournalJournal of the American College of Cardiology
Volume19
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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Dipyridamole
Heart Transplantation
Vasodilator Agents
Positron-Emission Tomography
Oxygen
Water
Pressure
Perfusion
Reference Values
Regional Blood Flow
Sclerosis
Vasodilation
Intravenous Administration
Heart Ventricles
Allografts
Myocardium
Transplantation
Heart Rate
Body Weight
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dipyridamole vasodilator response after human orthotopic heart transplantation : Quantification by oxygen-15-labeled water and positron emission tomography. / Rechavia, Eldad; Araujo, Luis I.; de Silva, Ranil; Kushwaha, Sudhir S.; Lammertsma, Adriaan A.; Jones, Terry; Mitchell, Andrew; Maseri, A'ttilio; Yacoub, Magdi H.

In: Journal of the American College of Cardiology, Vol. 19, No. 1, 1992, p. 100-106.

Research output: Contribution to journalArticle

Rechavia, Eldad ; Araujo, Luis I. ; de Silva, Ranil ; Kushwaha, Sudhir S. ; Lammertsma, Adriaan A. ; Jones, Terry ; Mitchell, Andrew ; Maseri, A'ttilio ; Yacoub, Magdi H. / Dipyridamole vasodilator response after human orthotopic heart transplantation : Quantification by oxygen-15-labeled water and positron emission tomography. In: Journal of the American College of Cardiology. 1992 ; Vol. 19, No. 1. pp. 100-106.
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title = "Dipyridamole vasodilator response after human orthotopic heart transplantation: Quantification by oxygen-15-labeled water and positron emission tomography",
abstract = "To assess coronary vasodilator restore after orthotopic heart transplantation, regional myocardial perfusion was measured with oxygen-15-labeled water and dynamic positron emission tomography in 14 cardiac allograft recipients who were not experiencing rejection and who had no angiographic evidence of epicardial coronary sclerosis 15 to 73 months (mean ± SD 43 ± 19) after transplantation (group I). Twelve normal men with an average age of 31 years (group II) served as a control group. Regional perfusion was measured at rest and after the intravenous administration of 0.6 mg/kg body weight of dipyridamole. Rest regional myocardial blood flow was homogeneously distributed throughout the left ventricle and was significantly higher in transplant recipients (mean 1.16 ± 0.26 ml/g per min [range 0.8 to 1.73] than in normal subjects mean 0.85 ± 0.13 ml/g per min [range 0.57 to 0.99); p = 0.001) as was rest heart rate-systoll blood pressure product (rate-pressure product 11,255 ± 2,540 vs. 7,073 ± 1,306; p < 0.001). After dipyridamole, perfusion in the transplant recipients was homogeneous and slightly lower (2.73 ±1.03 vs. 3.40 ± 1.09 ml/g per min; p = NS), whereas rate-pressure product was slightly higher (12,179 ± 2,266 vs. 10,885 ± 1,895: p = NS) than the value in normal subjects. Dipyridamole vasodilator response (dipyridamole/rest myocardial blood flow) ranged from 1.23 to 4.92 (mean 2.50 ± 1.13) in group I and from 2.65 to 5.45 (3.97 ± 0.89) in group II (p = 0.001). Rate-pressure product change (dipyridammole/rest rate-pressure product) was markedly attenuated in transplant recipients compred with the value in normal subjects (1.09 ± 0.09 vs. 1.56 ± 0.27 ml/g/per min; p < 0,001). Normalization for the difference in rest rate-pressure product for each individual subject showed that the adjusted rest show values (group 11.19 ± 0.27, group II 1.39 ± 0.31 ml/g per min; p = NS) and the dipyridamole-vasodilator response data (group I 2.45 ± 0.64, group II 2.47 ± 1.23, p = NS) in the two groups were not significantly different. Thus, in transplant recipients who are not experiencing rejection, the respons iveness of the coronary vasculature to dipyridamole-mediated vasodilation is uniformly preserved among all regions of the left ventricular myocardium.",
author = "Eldad Rechavia and Araujo, {Luis I.} and {de Silva}, Ranil and Kushwaha, {Sudhir S.} and Lammertsma, {Adriaan A.} and Terry Jones and Andrew Mitchell and A'ttilio Maseri and Yacoub, {Magdi H.}",
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T1 - Dipyridamole vasodilator response after human orthotopic heart transplantation

T2 - Quantification by oxygen-15-labeled water and positron emission tomography

AU - Rechavia, Eldad

AU - Araujo, Luis I.

AU - de Silva, Ranil

AU - Kushwaha, Sudhir S.

AU - Lammertsma, Adriaan A.

AU - Jones, Terry

AU - Mitchell, Andrew

AU - Maseri, A'ttilio

AU - Yacoub, Magdi H.

PY - 1992

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N2 - To assess coronary vasodilator restore after orthotopic heart transplantation, regional myocardial perfusion was measured with oxygen-15-labeled water and dynamic positron emission tomography in 14 cardiac allograft recipients who were not experiencing rejection and who had no angiographic evidence of epicardial coronary sclerosis 15 to 73 months (mean ± SD 43 ± 19) after transplantation (group I). Twelve normal men with an average age of 31 years (group II) served as a control group. Regional perfusion was measured at rest and after the intravenous administration of 0.6 mg/kg body weight of dipyridamole. Rest regional myocardial blood flow was homogeneously distributed throughout the left ventricle and was significantly higher in transplant recipients (mean 1.16 ± 0.26 ml/g per min [range 0.8 to 1.73] than in normal subjects mean 0.85 ± 0.13 ml/g per min [range 0.57 to 0.99); p = 0.001) as was rest heart rate-systoll blood pressure product (rate-pressure product 11,255 ± 2,540 vs. 7,073 ± 1,306; p < 0.001). After dipyridamole, perfusion in the transplant recipients was homogeneous and slightly lower (2.73 ±1.03 vs. 3.40 ± 1.09 ml/g per min; p = NS), whereas rate-pressure product was slightly higher (12,179 ± 2,266 vs. 10,885 ± 1,895: p = NS) than the value in normal subjects. Dipyridamole vasodilator response (dipyridamole/rest myocardial blood flow) ranged from 1.23 to 4.92 (mean 2.50 ± 1.13) in group I and from 2.65 to 5.45 (3.97 ± 0.89) in group II (p = 0.001). Rate-pressure product change (dipyridammole/rest rate-pressure product) was markedly attenuated in transplant recipients compred with the value in normal subjects (1.09 ± 0.09 vs. 1.56 ± 0.27 ml/g/per min; p < 0,001). Normalization for the difference in rest rate-pressure product for each individual subject showed that the adjusted rest show values (group 11.19 ± 0.27, group II 1.39 ± 0.31 ml/g per min; p = NS) and the dipyridamole-vasodilator response data (group I 2.45 ± 0.64, group II 2.47 ± 1.23, p = NS) in the two groups were not significantly different. Thus, in transplant recipients who are not experiencing rejection, the respons iveness of the coronary vasculature to dipyridamole-mediated vasodilation is uniformly preserved among all regions of the left ventricular myocardium.

AB - To assess coronary vasodilator restore after orthotopic heart transplantation, regional myocardial perfusion was measured with oxygen-15-labeled water and dynamic positron emission tomography in 14 cardiac allograft recipients who were not experiencing rejection and who had no angiographic evidence of epicardial coronary sclerosis 15 to 73 months (mean ± SD 43 ± 19) after transplantation (group I). Twelve normal men with an average age of 31 years (group II) served as a control group. Regional perfusion was measured at rest and after the intravenous administration of 0.6 mg/kg body weight of dipyridamole. Rest regional myocardial blood flow was homogeneously distributed throughout the left ventricle and was significantly higher in transplant recipients (mean 1.16 ± 0.26 ml/g per min [range 0.8 to 1.73] than in normal subjects mean 0.85 ± 0.13 ml/g per min [range 0.57 to 0.99); p = 0.001) as was rest heart rate-systoll blood pressure product (rate-pressure product 11,255 ± 2,540 vs. 7,073 ± 1,306; p < 0.001). After dipyridamole, perfusion in the transplant recipients was homogeneous and slightly lower (2.73 ±1.03 vs. 3.40 ± 1.09 ml/g per min; p = NS), whereas rate-pressure product was slightly higher (12,179 ± 2,266 vs. 10,885 ± 1,895: p = NS) than the value in normal subjects. Dipyridamole vasodilator response (dipyridamole/rest myocardial blood flow) ranged from 1.23 to 4.92 (mean 2.50 ± 1.13) in group I and from 2.65 to 5.45 (3.97 ± 0.89) in group II (p = 0.001). Rate-pressure product change (dipyridammole/rest rate-pressure product) was markedly attenuated in transplant recipients compred with the value in normal subjects (1.09 ± 0.09 vs. 1.56 ± 0.27 ml/g/per min; p < 0,001). Normalization for the difference in rest rate-pressure product for each individual subject showed that the adjusted rest show values (group 11.19 ± 0.27, group II 1.39 ± 0.31 ml/g per min; p = NS) and the dipyridamole-vasodilator response data (group I 2.45 ± 0.64, group II 2.47 ± 1.23, p = NS) in the two groups were not significantly different. Thus, in transplant recipients who are not experiencing rejection, the respons iveness of the coronary vasculature to dipyridamole-mediated vasodilation is uniformly preserved among all regions of the left ventricular myocardium.

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