@inproceedings{0363ae6486a346069f7ac6f2fa0ab58d,
title = "Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution",
abstract = "Imaging protocols must obtain maximum information under tight time constraints, to minimize patient discomfort or attrition, and motion artifacts. As part of a pilot study optimizing DTI sequences for the Alzheimer's Disease Neuroimaging Initiative, we scanned 8 subjects with 3 DTI protocols of equal duration at two time-points (48 scans). If scan duration is fixed, collecting more diffusion-sensitized gradient directions can increase angular resolution at the expense of spatial. We compared 7-minute sequences with 3.0(48), 2.7(41), and 2.5(37) mm isotropic voxels (directions), to assess (1) SNR; (2) bias in estimating fiber anisotropy; (3) reproducibility over time; (4) intersubject variance-relevant for group comparisons. Statistical maps revealed that higher angular resolutions gave more reproducible estimates; FA depended on voxel size, with a steeper dependency in more heterogeneous regions. The intermediate resolution gave best SNR. 2mm DTI scans are common, but improved angular resolution may add temporal stability, and benefits for tractography.",
keywords = "Angular resolution, Diffusion tensor imaging (DTI), Imaging protocols, Signal to noise, Spatial resolution",
author = "Neda Jahanshad and Liang Zhan and Bernstein, {Matt A.} and Borowski, {Bret J.} and Jack, {Clifford R.} and Toga, {Arthur W.} and Thompson, {Paul M.}",
year = "2010",
doi = "10.1109/ISBI.2010.5490200",
language = "English (US)",
isbn = "9781424441266",
series = "2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings",
pages = "1161--1164",
booktitle = "2010 7th IEEE International Symposium on Biomedical Imaging",
note = "7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 ; Conference date: 14-04-2010 Through 17-04-2010",
}