Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution

Neda Jahanshad, Liang Zhan, Matt A. Bernstein, Bret J. Borowski, Clifford R. Jack, Arthur W. Toga, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Scopus citations

Abstract

Imaging protocols must obtain maximum information under tight time constraints, to minimize patient discomfort or attrition, and motion artifacts. As part of a pilot study optimizing DTI sequences for the Alzheimer's Disease Neuroimaging Initiative, we scanned 8 subjects with 3 DTI protocols of equal duration at two time-points (48 scans). If scan duration is fixed, collecting more diffusion-sensitized gradient directions can increase angular resolution at the expense of spatial. We compared 7-minute sequences with 3.0(48), 2.7(41), and 2.5(37) mm isotropic voxels (directions), to assess (1) SNR; (2) bias in estimating fiber anisotropy; (3) reproducibility over time; (4) intersubject variance-relevant for group comparisons. Statistical maps revealed that higher angular resolutions gave more reproducible estimates; FA depended on voxel size, with a steeper dependency in more heterogeneous regions. The intermediate resolution gave best SNR. 2mm DTI scans are common, but improved angular resolution may add temporal stability, and benefits for tractography.

Original languageEnglish (US)
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
Pages1161-1164
Number of pages4
DOIs
StatePublished - Aug 9 2010
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: Apr 14 2010Apr 17 2010

Publication series

Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Other

Other7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
CountryNetherlands
CityRotterdam
Period4/14/104/17/10

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Keywords

  • Angular resolution
  • Diffusion tensor imaging (DTI)
  • Imaging protocols
  • Signal to noise
  • Spatial resolution

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Jahanshad, N., Zhan, L., Bernstein, M. A., Borowski, B. J., Jack, C. R., Toga, A. W., & Thompson, P. M. (2010). Diffusion tensor imaging in seven minutes: Determining trade-offs between spatial and directional resolution. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 1161-1164). [5490200] (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490200