TY - JOUR
T1 - Diffusion tensor imaging comparison of progressive supranuclear palsy and corticobasal syndromes
AU - Whitwell, Jennifer L.
AU - Schwarz, Christopher G.
AU - Reid, Robert I.
AU - Kantarci, Kejal
AU - Jack, Clifford R.
AU - Josephs, Keith A.
N1 - Funding Information:
This study was funded by the Dana Foundation .
PY - 2014/5
Y1 - 2014/5
N2 - Background: Corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS) are atypical parkinsonian syndromes that are both associated with white matter tract degeneration. However, little is known about how patterns of degeneration compare across these two syndromes. Methods: Twenty-seven subjects, nine with CBS and eighteen with probable or definite PSPS (9 pathologically confirmed) were prospectively recruited and underwent 3.0T diffusion tensor imaging. A whole-brain voxel-based analysis was performed on fractional anisotropy (FA) and mean diffusivity (MD) images to compare both groups to each other and to 50 healthy controls. Results: The two syndromes showed overlapping regions of reduced FA and increased MD in the body of the corpus callosum, middle cingulum bundle, and premotor and prefrontal white matter, with reduced FA also observed in the superior cerebellar peduncles in both syndromes. However, CBS showed a more supratentorial and posterior pattern of degeneration with greater involvement of the splenium of the corpus callosum, premotor, motor and parietal lobes than PSPS. Findings in CBS were also highly asymmetric. Conversely, PSPS showed a more symmetric and infratentorial pattern of degeneration, with greater involvement of the superior cerebellar peduncles and midbrain than CBS. Conclusions: CBS and PSPS are both associated with striking white matter tract degeneration. Despite differences in the supratentorial and infratentorial distribution of degeneration, and in asymmetry, both tend to target a common structural network. Measurements of white matter tract diffusion could therefore be useful disease biomarkers in both of these syndromes.
AB - Background: Corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS) are atypical parkinsonian syndromes that are both associated with white matter tract degeneration. However, little is known about how patterns of degeneration compare across these two syndromes. Methods: Twenty-seven subjects, nine with CBS and eighteen with probable or definite PSPS (9 pathologically confirmed) were prospectively recruited and underwent 3.0T diffusion tensor imaging. A whole-brain voxel-based analysis was performed on fractional anisotropy (FA) and mean diffusivity (MD) images to compare both groups to each other and to 50 healthy controls. Results: The two syndromes showed overlapping regions of reduced FA and increased MD in the body of the corpus callosum, middle cingulum bundle, and premotor and prefrontal white matter, with reduced FA also observed in the superior cerebellar peduncles in both syndromes. However, CBS showed a more supratentorial and posterior pattern of degeneration with greater involvement of the splenium of the corpus callosum, premotor, motor and parietal lobes than PSPS. Findings in CBS were also highly asymmetric. Conversely, PSPS showed a more symmetric and infratentorial pattern of degeneration, with greater involvement of the superior cerebellar peduncles and midbrain than CBS. Conclusions: CBS and PSPS are both associated with striking white matter tract degeneration. Despite differences in the supratentorial and infratentorial distribution of degeneration, and in asymmetry, both tend to target a common structural network. Measurements of white matter tract diffusion could therefore be useful disease biomarkers in both of these syndromes.
KW - Diffusion tensor imaging
KW - Parkinsonism
KW - Premotor
KW - Structural network
KW - Superior cerebellar peduncle
KW - White matter
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U2 - 10.1016/j.parkreldis.2014.01.023
DO - 10.1016/j.parkreldis.2014.01.023
M3 - Article
C2 - 24656943
AN - SCOPUS:84900030381
SN - 1353-8020
VL - 20
SP - 493
EP - 498
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
IS - 5
ER -