Abstract
Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26-34 |
| Number of pages | 9 |
| Journal | Neurology |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 5 2011 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Diffusion tensor imaging and cognitive function in older adults with no dementia. / Kantarci, Kejal M; Senjem, M. L.; Avula, R.; Zhang, B.; Samikoglu, A. R.; Weigand, S. D.; Przybelski, S. A.; Edmonson, H. A.; Vemuri, Prashanthi D; Knopman, David S; Boeve, Bradley F; Ivnik, R. J.; Smith, G. E.; Petersen, Ronald Carl; Jack, Clifford R Jr.
In: Neurology, Vol. 77, No. 1, 05.07.2011, p. 26-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diffusion tensor imaging and cognitive function in older adults with no dementia
AU - Kantarci, Kejal M
AU - Senjem, M. L.
AU - Avula, R.
AU - Zhang, B.
AU - Samikoglu, A. R.
AU - Weigand, S. D.
AU - Przybelski, S. A.
AU - Edmonson, H. A.
AU - Vemuri, Prashanthi D
AU - Knopman, David S
AU - Boeve, Bradley F
AU - Ivnik, R. J.
AU - Smith, G. E.
AU - Petersen, Ronald Carl
AU - Jack, Clifford R Jr.
PY - 2011/7/5
Y1 - 2011/7/5
N2 - Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.
AB - Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.
UR - http://www.scopus.com/inward/record.url?scp=80051552544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051552544&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e31822313dc
DO - 10.1212/WNL.0b013e31822313dc
M3 - Article
C2 - 21593440
AN - SCOPUS:80051552544
VL - 77
SP - 26
EP - 34
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -