Diffusion tensor imaging and cognitive function in older adults with no dementia

Kejal M Kantarci, M. L. Senjem, R. Avula, B. Zhang, A. R. Samikoglu, S. D. Weigand, S. A. Przybelski, H. A. Edmonson, Prashanthi D Vemuri, David S Knopman, Bradley F Boeve, R. J. Ivnik, G. E. Smith, Ronald Carl Petersen, Clifford R Jr. Jack

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

Original languageEnglish (US)
Pages (from-to)26-34
Number of pages9
JournalNeurology
Volume77
Issue number1
DOIs
StatePublished - Jul 5 2011

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Diffusion Tensor Imaging
Anisotropy
Cognition
Dementia
Executive Function
Temporal Lobe
Language
Gyrus Cinguli
Color
Cross-Sectional Studies
Regression Analysis
Pathology
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Diffusion tensor imaging and cognitive function in older adults with no dementia. / Kantarci, Kejal M; Senjem, M. L.; Avula, R.; Zhang, B.; Samikoglu, A. R.; Weigand, S. D.; Przybelski, S. A.; Edmonson, H. A.; Vemuri, Prashanthi D; Knopman, David S; Boeve, Bradley F; Ivnik, R. J.; Smith, G. E.; Petersen, Ronald Carl; Jack, Clifford R Jr.

In: Neurology, Vol. 77, No. 1, 05.07.2011, p. 26-34.

Research output: Contribution to journalArticle

Kantarci, KM, Senjem, ML, Avula, R, Zhang, B, Samikoglu, AR, Weigand, SD, Przybelski, SA, Edmonson, HA, Vemuri, PD, Knopman, DS, Boeve, BF, Ivnik, RJ, Smith, GE, Petersen, RC & Jack, CRJ 2011, 'Diffusion tensor imaging and cognitive function in older adults with no dementia', Neurology, vol. 77, no. 1, pp. 26-34. https://doi.org/10.1212/WNL.0b013e31822313dc
Kantarci, Kejal M ; Senjem, M. L. ; Avula, R. ; Zhang, B. ; Samikoglu, A. R. ; Weigand, S. D. ; Przybelski, S. A. ; Edmonson, H. A. ; Vemuri, Prashanthi D ; Knopman, David S ; Boeve, Bradley F ; Ivnik, R. J. ; Smith, G. E. ; Petersen, Ronald Carl ; Jack, Clifford R Jr. / Diffusion tensor imaging and cognitive function in older adults with no dementia. In: Neurology. 2011 ; Vol. 77, No. 1. pp. 26-34.
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AU - Kantarci, Kejal M

AU - Senjem, M. L.

AU - Avula, R.

AU - Zhang, B.

AU - Samikoglu, A. R.

AU - Weigand, S. D.

AU - Przybelski, S. A.

AU - Edmonson, H. A.

AU - Vemuri, Prashanthi D

AU - Knopman, David S

AU - Boeve, Bradley F

AU - Ivnik, R. J.

AU - Smith, G. E.

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

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N2 - Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

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