Diffusion tensor imaging and cognitive function in older adults with no dementia

K. Kantarci; M. L. Senjem; R. Avula; B. Zhang; A. R. Samikoglu; S. D. Weigand; S. A. Przybelski; H. A. Edmonson; P. Vemuri; D. S. Knopman; B. F. Boeve; R. J. Ivnik; G. E. Smith; R. C. Petersen; C. R. Jack

doi:10.1212/WNL.0b013e31822313dc

Diffusion tensor imaging and cognitive function in older adults with no dementia

K. Kantarci, M. L. Senjem, R. Avula, B. Zhang, A. R. Samikoglu, S. D. Weigand, S. A. Przybelski, H. A. Edmonson, P. Vemuri, D. S. Knopman, B. F. Boeve, R. J. Ivnik, G. E. Smith, R. C. Petersen, C. R. Jack

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

Original language	English (US)
Pages (from-to)	26-34
Number of pages	9
Journal	Neurology
Volume	77
Issue number	1
DOIs	https://doi.org/10.1212/WNL.0b013e31822313dc
State	Published - Jul 5 2011

ASJC Scopus subject areas

Clinical Neurology

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Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Petersen, R. C., & Jack, C. R. (2011). Diffusion tensor imaging and cognitive function in older adults with no dementia. Neurology, 77(1), 26-34. https://doi.org/10.1212/WNL.0b013e31822313dc

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title = "Diffusion tensor imaging and cognitive function in older adults with no dementia",

abstract = "Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.",

author = "K. Kantarci and Senjem, {M. L.} and R. Avula and B. Zhang and Samikoglu, {A. R.} and Weigand, {S. D.} and Przybelski, {S. A.} and Edmonson, {H. A.} and P. Vemuri and Knopman, {D. S.} and Boeve, {B. F.} and Ivnik, {R. J.} and Smith, {G. E.} and Petersen, {R. C.} and Jack, {C. R.}",

note = "Funding Information: Study funding: Supported by the NIH (K23 AG030935, P50 AG16574/P1, R01 AG11378, U01 AG 06786) . Support for several investigators was provided by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation and the NIH Construction Grant (C06 RR018898) . ",

year = "2011",

month = jul,

day = "5",

doi = "10.1212/WNL.0b013e31822313dc",

language = "English (US)",

volume = "77",

pages = "26--34",

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TY - JOUR

T1 - Diffusion tensor imaging and cognitive function in older adults with no dementia

AU - Kantarci, K.

AU - Senjem, M. L.

AU - Avula, R.

AU - Zhang, B.

AU - Samikoglu, A. R.

AU - Weigand, S. D.

AU - Przybelski, S. A.

AU - Edmonson, H. A.

AU - Vemuri, P.

AU - Knopman, D. S.

AU - Boeve, B. F.

AU - Ivnik, R. J.

AU - Smith, G. E.

AU - Petersen, R. C.

AU - Jack, C. R.

N1 - Funding Information: Study funding: Supported by the NIH (K23 AG030935, P50 AG16574/P1, R01 AG11378, U01 AG 06786) . Support for several investigators was provided by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation and the NIH Construction Grant (C06 RR018898) .

PY - 2011/7/5

Y1 - 2011/7/5

N2 - Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

AB - Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.

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Diffusion tensor imaging and cognitive function in older adults with no dementia

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