@article{92b2a1e4c0f8418aa5bfbca04638278a,
title = "Diffusion tensor imaging and cognitive function in older adults with no dementia",
abstract = "Objective: To determine the patterns of diffusivity associated with cognitive domain functions in older adults without dementia. Methods: We studied older adults without dementia (n = 220) who underwent neuropsychometric testing and a diffusion tensor imaging (DTI) examination at 3 T in a cross-sectional study. Memory, language, attention/executive function, and visual-spatial processing domains were assessed within 4 months of the MRI examination. A fluid-attenuated inversion recovery-based DTI sequence that enabled uncontaminated cortical diffusion measurements was performed. Associations between cortical mean diffusivity (MD) and cognitive function were tested using voxel-based regression analysis. Association between tract diffusivity and cognitive function was tested with regions of interest drawn on color-coded fractional anisotropy (FA) maps. Results: Memory function was associated with the medial temporal lobe cortical MD on voxelbased analysis (p < 0.001, corrected for multiple comparisons), and inferior longitudinal fasciculus and posterior and anterior cingulum FA on tract-based analysis (p < 0.001). Language function was associated with the left temporal lobe corticalMD(p<0.001, corrected for multiple comparisons), inferior longitudinal fasciculus, fornix, and posterior cingulum FA (p < 0.05). Attention and executive function was associated with the posterior and anterior cingulum FA, and visual-spatial function was associated with posterior cingulum FA (p < 0.01). Conclusion: Specific cognitive domain functions are associated with distinct patterns of cortical and white matter diffusivity in elderly with no dementia. Posterior cingulum tract FA was associated with all 4 cognitive domain functions, in agreement with the hypothesis that the posterior cingulate cortex is the main connectivity hub for cognitive brain networks. Microstructural changes identified on DTI may be associated with neurodegenerative pathologies underlying cognitive changes in older adults without dementia.",
author = "K. Kantarci and Senjem, {M. L.} and R. Avula and B. Zhang and Samikoglu, {A. R.} and Weigand, {S. D.} and Przybelski, {S. A.} and Edmonson, {H. A.} and P. Vemuri and Knopman, {D. S.} and Boeve, {B. F.} and Ivnik, {R. J.} and Smith, {G. E.} and Petersen, {R. C.} and Jack, {C. R.}",
note = "Funding Information: Dr. Kantarci receives research support from the NIH. M.L. Senjem has received research support from Pfizer Inc. Dr. Avula serves as a consultant for Medical Imaging Solutions. Dr. Zhang, A.R. Samikoglu, S.D. Weigand, and S.A. Przybelski report no disclosures. Dr. Edmonson is author on a patent re: Real-time shimming of polarizing field in magnetic resonance system; receives research support from the NIH (NIA, NCRR, NIBIB, NIMH), NARSAD The Brain and Behavior Research Fund; has received license fee payments for ACR phantom analysis software; and has received royalty payments from Siemens for a patent re: Real-time shimming of polarizing field in magnetic resonance system. Dr. Vemuri reports no disclosures. Dr. Knopman serves as Deputy Editor for Neurology {\textregistered} ; has served on a data safety monitoring board for Eli Lilly and Company; has served as a consultant for Elan/Janssen AI; is an investigator in clinical trials sponsored by Elan/Janssen AI, Baxter International Inc., and Forest Laboratories, Inc.; and receives research support from the NIH. Dr. Boeve receives royalties from the publication of Behavioral Neurology of Dementia (Cambridge University Press, 2009); has served as a consultant for GE Healthcare; and receives research support from Cephalon, Inc., Allon Therapeutics, Inc., the NIH/NIA, and the Alzheimer's Association, and the Mangurian Foundation. Dr. Ivnik serves on the editorial boards of The Clinical Neuropsychologist and Aging, Neuropsychology, and Cognition; receives publishing royalties for Clinical Interpretation of the WAIS-III and WMS-III (Academic Press, 2003); and receives research support from the NIH/NIA. Dr. Smith serves on the editorial boards of The Clinical Neuropsychologist and the Journal of International Neuropsychological Society; serves as a consultant for Homeinstead Senior Living Inc.; and receives research support from the NIH (NCRR, NIA, NINDS) and Mayo Clinic Alzheimer's Disease Research Center. Dr. Petersen serves on scientific advisory boards for the Alzheimer's Association, the National Advisory Council on Aging (NIA), Elan/Janssen AI, Pfizer Inc (Wyeth), and GE Healthcare; receives royalties from publishing Mild Cognitive Impairment (Oxford University Press, 2003); serves as a consultant for Elan/Janssen AI and GE Healthcare; and receives research support from the NIH/NIA. Dr. Jack serves on scientific advisory boards for Elan/Janssen AI, Eli Lilly & Company, GE Healthcare, and Eisai Inc.; receives research support from Baxter International Inc., Allon Therapeutics, Inc., Pfizer Inc, the NIH/NIA, and the Alexander Family Alzheimer's Disease Research Professorship of the Mayo Foundation; and holds stock/stock options in Johnson & Johnson. Funding Information: Study funding: Supported by the NIH (K23 AG030935, P50 AG16574/P1, R01 AG11378, U01 AG 06786) . Support for several investigators was provided by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program of the Mayo Foundation and the NIH Construction Grant (C06 RR018898) . ",
year = "2011",
month = jul,
day = "5",
doi = "10.1212/WNL.0b013e31822313dc",
language = "English (US)",
volume = "77",
pages = "26--34",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",
}