Diffuse pulmonary disease caused by nontuberculous mycobacteria in immunocompetent people (Hot tub lung)

A. Khoor, K. O. Leslie, H. D. Tazelaar, R. A. Helmers, T. V. Colby

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

The clinicopathologic spectrum of infections due to nontuberculous mycobacteria (NTM) includes cavitary disease, opportunistic infection, and nodular disease associated with bronchiectasis. We report a less well-described manifestation of NTM infection: 10 immunocompetent patients without preexisting bronchiectasis had radiographic evidence of diffuse infiltrative lung disease. The most common symptoms were dyspnea, cough, hypoxia, and fever. All 10 patients had used a hot tub. Histologic examination revealed exuberant nonnecrotizing, frequently bronchiolocentric, granulomatous inflammation in all cases. In 1 case, necrotizing granulomas were also noted. The inflammation often was associated with patchy chronic interstitial pneumonia and organization. Cultures revealed NTM in all cases (Mycobacterium avium complex in all but 1 case), but staining for acid-fast bacilli was positive in only 1 case. Four patients received corticosteroids alone for presumed hypersensitivity pneumonia, 4 were treated with antimycobacterial therapy, and 2 received both. All patients demonstrated significant improvement at the time of follow-up. These findings suggest that disease due to NTM may manifest as diffuse infiltrates in immunocompetent adults and that hot tub use may be an important risk factor for this disease pattern.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalAmerican journal of clinical pathology
Volume115
Issue number5
DOIs
StatePublished - Nov 22 2001

Keywords

  • Granulomas
  • Hot tub
  • Lung disease
  • Mycobacterium avium complex
  • Nontuberculous mycobacteria

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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